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Leukemia & Lymphoma Volume 49, 2008 - Issue 6
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Original Article: Clinical

Serum immunoglobulin free light chain correlates with tumor burden markers in Waldenstrom macroglobulinemia

Xavier Leleu Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School Boston, MA, USA; Service des Maladies du Sang, CHRU, Lille, France
,
Anne-Sophie Moreau Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School Boston, MA, USA; Service des Maladies du Sang, CHRU, Lille, France
,
Edie Weller Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard School of Public Health Boston, MA, USA
,
Aldo M. Roccaro Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School Boston, MA, USA
,
ValéRie Coiteux Service des Maladies du Sang, CHRU, Lille, France
,
Robert Manning Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School Boston, MA, USA
,
Marybeth Nelson Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School Boston, MA, USA
,
Renee Leduc Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School Boston, MA, USA
,
Daniela Robu Service des Maladies du Sang, CHRU, Lille, France
,
Sophie Dupire Service des Maladies du Sang, CHRU, Lille, France
,
Evdoxia Hatjiharissi Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School Boston, MA, USA
,
Nicholas Burwick Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School Boston, MA, USA
,
Stéphane Darre Service des Maladies du Sang, CHRU, Lille, France
,
Bernadette Hennache Laboratoire de Biochimie, CHRU, Lille, France
,
Steven P. Treon Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School Boston, MA, USA
,
Thierry Facon Service des Maladies du Sang, CHRU, Lille, France
,
Morie A. Gertz Mayo Clinic College of Medicine, Division of Hematology, Mayo Clinic, RochesterUSA
&
Irene M. Ghobrial Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School Boston, MA, USACorrespondence[email protected]
, MD show all
Pages 1104-1107 | Received 05 Feb 2008, Accepted 21 Mar 2008, Published online: 01 Jul 2009
 
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Abstract

The serum IgM level has been utilised as a marker of tumor progression and to assess response to therapy in patients with Waldenstrom macroglobulinemia (WM). However, there are many limitations to the IgM protein level. The objective of this study was to evaluate the association of known tumor burden markers and prognostic factors with serum free light chain (sFLC) in 98 patients with WM. We demonstrated that sFLC measurement accurately differentiated IgM-MGUS compared with WM reflecting a measurement of tumor burden. In univariate and multivariate analysis, median sFLC at the cut-off at 60 mg/L was higher for WM patients with low hemoglobin and high β2M, when we applied the WM-IPSS cut-offs, but showed no association with IgM level. This study demonstrates that sFLC is a new marker in WM disease. Further analysis is required to prospectively study the role of sFLC in monitoring response to therapy and as a prognostic marker in WM patients.

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