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Leukemia & Lymphoma Volume 57, 2016 - Issue 12
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Original Article: Clinical

Primary bone diffuse large B-cell lymphoma: a retrospective evaluation on 76 cases from French institutional and LYSA studies

Sylvain PilorgeHematology Department, Cochin Hospital, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France; ;Faculté de Médecine Sorbonne Paris Cité, Université Paris Descartes, Paris, France;
,
Stephanie HarelLymphoid Malignancies Unit, Saint Louis Hospital, Paris, France;
,
Vincent RibragGustave Roussy Institute, Villejuif, Paris, France;
,
Frédérique LarousserieFaculté de Médecine Sorbonne Paris Cité, Université Paris Descartes, Paris, France; ;Pathology Department, Cochin Hospital, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France;
,
Lise WillemsHematology Department, Cochin Hospital, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France; ;Faculté de Médecine Sorbonne Paris Cité, Université Paris Descartes, Paris, France;
,
Patricia FranchiHematology Department, Cochin Hospital, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France; ;Faculté de Médecine Sorbonne Paris Cité, Université Paris Descartes, Paris, France;
,
Marielle LegoffHematology Department, Cochin Hospital, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France; ;Faculté de Médecine Sorbonne Paris Cité, Université Paris Descartes, Paris, France;
,
David BiauFaculté de Médecine Sorbonne Paris Cité, Université Paris Descartes, Paris, France; ;Orthopedic Surgery Department, Cochin Hospital, AP-HP, Paris, France;
,
Philippe AnractFaculté de Médecine Sorbonne Paris Cité, Université Paris Descartes, Paris, France; ;Orthopedic Surgery Department, Cochin Hospital, AP-HP, Paris, France;
,
Christian RouxFaculté de Médecine Sorbonne Paris Cité, Université Paris Descartes, Paris, France; ;Rhumatology Department, Cochin Hospital, AP-HP, Paris, France;
,
Estelle Blanc-AutranNuclear Medicine Department, Centre Medico-Chirurgical Marie-Lannelongue, Le Plessis-Robinson, France;
,
Richard DelarueHematology Department, Necker Hospital, Paris, France;
,
Christian GisselbrechtService Onco-Hématologie Hôpital Saint Louis, Paris, France;
,
Nicolas KettererClinique Bois-Cerf, Lausanne, Switzerland;
,
Christian RecherService d'Hématologie, Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France;
,
Christophe BonnetDépartement de Médecine, Service d'Hématologie Clinique, CHU Liège, Campus Universitaire du Sart-Tilman, Belgique;
,
Frederic PeyradeDepartment of Oncology, Antoine-Lacassagne Center, Nice, France;
,
Corinne HaiounDepartment of Hematology, Henri Mondor University Hospital, Créteil, France;
,
Hervé TillyCentre Henri-Becquerel, Université de Rouen, Rouen, France;
,
Gilles SallesCentre Hospitalier Lyon Sud, Service d'Hématologie, Hospices Civils de Lyon, Lyon, France
,
Pauline BriceLymphoid Malignancies Unit, Saint Louis Hospital, Paris, France;
,
Didier BouscaryHematology Department, Cochin Hospital, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France; ;Faculté de Médecine Sorbonne Paris Cité, Université Paris Descartes, Paris, France;
,
Bénédicte DeauHematology Department, Cochin Hospital, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France; ;Faculté de Médecine Sorbonne Paris Cité, Université Paris Descartes, Paris, France; Correspondence[email protected] [email protected]
&
Jerome TamburiniHematology Department, Cochin Hospital, Assistance Publique – Hôpitaux de Paris (AP-HP), Paris, France; ;Faculté de Médecine Sorbonne Paris Cité, Université Paris Descartes, Paris, France;
show all
Pages 2820-2826 | Received 25 Nov 2015, Accepted 02 Apr 2016, Published online: 27 Apr 2016
 
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Abstract

Primary bone diffuse large B-cell lymphoma (PB-DLBCL) is a rare DLBCL location variant. We treated 76 PB-DLBCL patients by immuno-chemotherapy, resulting in an 84% sustained complete remission rate and a 78.9% survival over a 4.7-year median follow-up period. Ann Arbor stage IV and high age-adjusted international prognostic index were predictive of adverse outcome in univariate analysis. In multivariate analysis using a Cox model, only aa-IPI predicted long-term survival. While based on a limited number of cases, we suggested that radiotherapy may be useful as a consolidation modality in PB-DLBCL. We also suggested that positron emission tomography/CT scan should be interpreted with caution due to a persistent [18F]fluorodeoxyglucose [18FDG] uptake of bone lesions even after remission in some in PB-DLBCL patients. Our study based on a homogeneous cohort of PB-DLBCL patients confirmed the favorable outcome of this DLBCL variant and support the implementation of prospective clinical trials in this disease.

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Corrigendum

Acknowledgments

We thank the whole LYSARC team − and especially Sami Boussetta − for their contribution to this work. We also thank all the clinicians involved in the LNH03B program and those from Cochin, Saint Louis and Institut Gustave Roussy hospitals that provided care to the patients.

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article at http://dx.doi.org/10.1080/10428194.2016.1177180.

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