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Leukemia & Lymphoma Volume 57, 2016 - Issue 12
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Original Article: Clinical

The SIL index is a simple and objective prognostic indicator in diffuse large B-cell lymphoma

Naoto TomitaDepartment of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan; Correspondence[email protected]
,
Taisei SuzukiDepartment of Hematology, Yokosuka City Hospital, Yokosuka, Japan;
,
Kazuho MiyashitaDepartment of Hematology/Immunology, Fujisawa City Hospital, Fujisawa, Japan;
,
Wataru YamamotoDepartment of Medical Oncology, Kanagawa Cancer Center, Yokohama, Japan;
,
Kenji MotohashiDepartment of Hematology, Yokohama City University Medical Center, Yokohama, Japan;
,
Takayoshi TachibanaDepartment of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan;
,
Hirotaka TakasakiDepartment of Medical Oncology, Kanagawa Cancer Center, Yokohama, Japan;
,
Rika KawasakiDepartment of Hematology/Immunology, Fujisawa City Hospital, Fujisawa, Japan;
,
Maki HagiharaDepartment of Hematology, Yokohama City University Medical Center, Yokohama, Japan;
,
Chizuko HashimotoDepartment of Hematology/Oncology, Yamato Municipal Hospital, Yamato, Japan;
,
Sachiya TakemuraDepartment of Internal Medicine, Yokohama Ekisaikai Hospital, Yokohama, Japan;
,
Hideyuki KoharazawaDepartment of Hematology, Shizuoka Red Cross Hospital, Shizuoka, Japan;
,
Etsuko YamazakiDepartment of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan;
,
Jun TaguchiDepartment of Hematology, Shizuoka Red Cross Hospital, Shizuoka, Japan;
,
Katsumichi FujimakiDepartment of Hematology/Immunology, Fujisawa City Hospital, Fujisawa, Japan;
,
Hiroyuki FujitaDepartment of Hematology, Saiseikai Yokohama Nanbu Hospital, Yokohama, Japan;
,
Rika SakaiDepartment of Medical Oncology, Kanagawa Cancer Center, Yokohama, Japan;
,
Shin FujisawaDepartment of Hematology, Yokohama City University Medical Center, Yokohama, Japan;
,
Shigeki MotomuraDepartment of Medical Oncology, Kanagawa Cancer Center, Yokohama, Japan;
,
Keisuke KawamotoDepartment of Hematology, Endocrinology, and Metabolism, Niigata University Faculty of Medicine, Niigata, Japan
,
Hirohito SoneDepartment of Hematology, Endocrinology, and Metabolism, Niigata University Faculty of Medicine, Niigata, Japan
&
Jun TakizawaDepartment of Hematology, Endocrinology, and Metabolism, Niigata University Faculty of Medicine, Niigata, Japan
 show all
Pages 2763-2770 | Received 10 Feb 2016, Accepted 24 May 2016, Published online: 20 Jun 2016
 
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Abstract

We previously developed a prognostic index, SIL, which includes advanced stage (S), soluble interleukin-2 receptor level (I), and elevated lactate dehydrogenase level (L) in diffuse large B-cell lymphoma (DLBCL) patients treated with rituximab, cyclophosphamide, hydroxydaunomycin, oncovin, and prednisone (R-CHOP). This time we evaluated the index in a larger cohort and its utility in the risk stratification. The above three factors were independent risk of progression-free survival (PFS). Five-year PFS rates in the standard-risk (SIL index: 0 or 1, n = 367) and high-risk groups (SIL index: 2 or 3, n = 205) were 79% and 53%, respectively (p < 0.0001). When the patients were divided by age (≤60 years and >60 years), the SIL index was a good prognostic indicator for PFS in both groups as well as divided by the number of extranodal involvement site (0–1 and >1). The SIL index is a simple and objective prognostic indicator in DLBCL.

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article at http://dx.doi.org/10.1080/10428194.2016.1195498.

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