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Leukemia & Lymphoma Volume 58, 2017 - Issue 4
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Original Articles: Clinical

T-cell subsets in lymph nodes identify a subgroup of follicular lymphoma patients with favorable outcome

Laura MagnanoDepartment of Hematology, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain;
,
Antonio MartínezHematopathology Unit, Department of Pathology, Hospital Clínic, IDIBAPS, Barcelona, Spain; ;Pathology Department, University of Barcelona, Barcelona, Spain;
,
Joaquim CarrerasHematopathology Unit, Department of Pathology, Hospital Clínic, IDIBAPS, Barcelona, Spain; ;Department of Pathology, School of Medicine, Tokai University, Isehara, Japan
,
Alejandra Martínez-TrillosDepartment of Hematology, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain;
,
Eva GinéDepartment of Hematology, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain;
,
Jordina RoviraDepartment of Hematology, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain;
,
Ivan DlouhyDepartment of Hematology, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain;
,
Tycho BaumannDepartment of Hematology, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain;
,
Olga BalaguéHematopathology Unit, Department of Pathology, Hospital Clínic, IDIBAPS, Barcelona, Spain;
,
Elías CampoHematopathology Unit, Department of Pathology, Hospital Clínic, IDIBAPS, Barcelona, Spain; ;Pathology Department, University of Barcelona, Barcelona, Spain;
,
Armando López-GuillermoDepartment of Hematology, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain;
&
Neus VillamorHematopathology Unit, Department of Pathology, Hospital Clínic, IDIBAPS, Barcelona, Spain; Correspondence[email protected]
 show all
Pages 842-850 | Received 25 Feb 2016, Accepted 18 Jul 2016, Published online: 11 Aug 2016
 
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Abstract

We have analyzed in lymph nodes at diagnosis of 75 patients with follicular lymphoma (FL) the relationship between different T-cell subpopulations, assessed by immunohistochemistry (IHC) and flow cytometry (FC), with the outcome. CD4+ cells were the most abundant T-cells in tumor tissue sections, whilst CD57+ cells were the less frequent. In addition to nonambulatory performance status, advanced stage and FLIPI, low CD4+CD57+/CD4+ ratio (p = .041), and low CD4+/CD8+ ratio (p = .008) predicted poor overall survival (OS). Multivariate analysis showed that CD4+CD57+/CD4+ ratio was the most important variable for OS. In conclusion, T-cell subpopulations, including CD4+CD57+/CD4+ ratio analyzed by FC, could identify FL patients with favorable outcome.

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article at http://dx.doi.org/10.1080/10428194.2016.1217525.

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