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Leukemia & Lymphoma Volume 58, 2017 - Issue 6
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Original Articles: Research

Characterization and prognostic relevance of circulating microvesicles in chronic lymphocytic leukemia

Luciana De LucaLaboratory of Preclinical and Translational Research, IRCCS Referral Cancer Center of Basilicata (CROB), Rionero in Vulture, PZ, Italy; Correspondence[email protected]
,
Giovanni D’ArenaDepartment of Onco-Hematology, IRCCS Referral Cancer Center of Basilicata (CROB), Rionero in Vulture, PZ, Italy;
,
Vittorio SimeonLaboratory of Preclinical and Translational Research, IRCCS Referral Cancer Center of Basilicata (CROB), Rionero in Vulture, PZ, Italy;
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Stefania TrinoLaboratory of Preclinical and Translational Research, IRCCS Referral Cancer Center of Basilicata (CROB), Rionero in Vulture, PZ, Italy;
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Ilaria LaurenzanaLaboratory of Preclinical and Translational Research, IRCCS Referral Cancer Center of Basilicata (CROB), Rionero in Vulture, PZ, Italy;
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Antonella CaivanoLaboratory of Preclinical and Translational Research, IRCCS Referral Cancer Center of Basilicata (CROB), Rionero in Vulture, PZ, Italy;
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Francesco La RoccaLaboratory of Preclinical and Translational Research, IRCCS Referral Cancer Center of Basilicata (CROB), Rionero in Vulture, PZ, Italy;
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Oreste VillaniDepartment of Onco-Hematology, IRCCS Referral Cancer Center of Basilicata (CROB), Rionero in Vulture, PZ, Italy;
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Giovanna MansuetoDepartment of Onco-Hematology, IRCCS Referral Cancer Center of Basilicata (CROB), Rionero in Vulture, PZ, Italy;
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Silvia DeaglioDepartment of Medical Sciences, University of Turin and Human Genetics Foundation (HuGeF), Turin, Italy;
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Idanna InnocentiDepartment of Hematology, Catholic University of Sacred Heart, Rome, Italy;
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Luca LaurentiDepartment of Hematology, Catholic University of Sacred Heart, Rome, Italy;
,
Stefano MolicaDepartment of Hematology, Ciaccio-Pugliese Hospital, Catanzaro, Italy;
,
Giuseppe PietrantuonoDepartment of Onco-Hematology, IRCCS Referral Cancer Center of Basilicata (CROB), Rionero in Vulture, PZ, Italy;
,
Angelo De StradisInstitute for Sustainable Plant Protection, National Research Council of Italy, University of Bari, Bari, Italy;
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Luigi Del VecchioDepartment of Molecular Medicine and Medical Biotechnologies, Federico II University, Naples, Italy; ;CEINGE-Biotecnologie Avanzate S.C.a R.L, Naples, Italy;
&
Pellegrino MustoScientific Direction, IRCCS Referral Cancer Center of Basilicata (CROB), Rionero in Vulture, PZ, Italy
 show all
Pages 1424-1432 | Received 23 Aug 2016, Accepted 27 Sep 2016, Published online: 14 Oct 2016
 
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Abstract

Microvescicles (MV) are shedding particles released by normal and neoplastic cells, whose levels in biological fluids highlight their potential role as disease biomarkers and therapeutic targets. By analyzing 131 newly diagnosed chronic lymphocytic leukemia (CLL), we found that the absolute number of serum CLL MV was significantly higher than in controls, in particular in advanced stages of disease. In addition, CD19 + and CD37+, B-cell derived MV, significantly correlated with high tumor burden. Absolute MV number cutoff selected by ROC analysis distinguished Rai stage 0 patients with shorter time to treatment (TTT) from those with more stable disease. Likewise, in the entire cohort, two groups of patients with different overall survival (OS) and different TTT were identified. At multivariate analysis, serum MV independently predicted for OS (along with Rai stage) and TTT (along with Rai stage, lymphocytes and CD38). In conclusion, circulating MV represent a new potential prognostic biomarker in CLL.

Acknowledgments

This research was supported by Italian ministry of Health, Current Research Funds for IRCCS [CUP E66J12000230001].

All authors have read the journal’s authorship agreement.

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article online at http://dx.doi.org/10.1080/10428194.2016.1243790.

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