Association of methylenetetrahydrofolate reductase gene–gene interaction and haplotype with susceptibility to acute lymphoblastic leukemia in Chinese children

Abstract

The aim of this study was to investigate the association of methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and additional gene–gene interaction with acute lymphoblastic leukemia (ALL) risk. Logistic regression was performed to investigate the association between two single nucleotide polymorphisms (SNPs) within MTHFR gene and ALL risk and additional gene–gene interaction between rs1801133 and rs1801131. The minor allele of rs1801133 and rs1801131 is associated with decreased ALL risk, OR (95% CI) were 0.61 (0.38–0.89), and 0.68 (0.50–0.96), respectively. We also found a significantly interaction between the two SNPs, participants with rs1801133 – CT or TT and rs1801131 – AC or CC genotype have the lowest ALL risk, compared with participants with rs1801133 – CC and rs1801131 – AA genotype, OR (95% CI) was 0.32 (0.12–0.63). We did not find any haplotype between the rs1801133 and rs1801131 associated with ALL risk. rs1801133 and rs1801131 within MTHFR gene and their interaction were both associated with ALL risk in Chinese children.

Keywords:

• Acute lymphoblastic leukemia
• MTHFR gene
• SNP
• interaction
• haplotype

Acknowledgements

The writing of this paper was supported by the Tumor Hospital of Gansu Province. We thank all the partners and staffs who help us in the process of this study.

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article at http://dx.doi.org/10.1080/10428194.2016.1265117.