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Leukemia & Lymphoma Volume 58, 2017 - Issue 11
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Original Articles: Research

Gene expression analysis of hypersensitivity to mosquito bite, chronic active EBV infection and NK/T-lymphoma/leukemia

Kana WashioDepartment of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; ;Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; View further author information
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Takashi OkaDepartment of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; Correspondence[email protected]
View further author information
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Lamia AbdalkaderDepartment of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; ;Department of Pathology, Faculty of Medicine, Mansoura University, Egypt; View further author information
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Michiko MuraokaDepartment of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; View further author information
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Akira ShimadaDepartment of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; View further author information
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Megumi OdaDepartment of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; View further author information
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Hiaki SatoDepartment of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; View further author information
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Katsuyoshi TakataDepartment of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; View further author information
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Yoshitoyo KagamiDivision of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan; View further author information
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Norio ShimizuDepartment of Virology, Division of Virology & Immunology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan; View further author information
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Seiichi KatoDepartment of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan; View further author information
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Hiroshi KimuraDepartment of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan; View further author information
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Kazunori NishizakiDepartment of Otorhinolaryngology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, JapanView further author information
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Tadashi YoshinoDepartment of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; View further author information
&
Hirokazu TsukaharaDepartment of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; View further author information
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Pages 2683-2694 | Received 05 Jun 2016, Accepted 06 Mar 2017, Published online: 03 Apr 2017
 
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Abstract

The human herpes virus, Epstein-Barr virus (EBV), is a known oncogenic virus and plays important roles in life-threatening T/NK-cell lymphoproliferative disorders (T/NK-cell LPD) such as hypersensitivity to mosquito bite (HMB), chronic active EBV infection (CAEBV), and NK/T-cell lymphoma/leukemia. During the clinical courses of HMB and CAEBV, patients frequently develop malignant lymphomas and the diseases passively progress sequentially. In the present study, gene expression of CD16(−)CD56(+)-, EBV(+) HMB, CAEBV, NK-lymphoma, and NK-leukemia cell lines, which were established from patients, was analyzed using oligonucleotide microarrays and compared to that of CD56brightCD16dim/− NK cells from healthy donors. Principal components analysis showed that CAEBV and NK-lymphoma cells were relatively closely located, indicating that they had similar expression profiles. Unsupervised hierarchal clustering analyses of microarray data and gene ontology analysis revealed specific gene clusters and identified several candidate genes responsible for disease that can be used to discriminate each category of NK-LPD and NK-cell lymphoma/leukemia.

Acknowledgements

The authors gratefully acknowledge Dr. K. Iwatsuki (Okayama University, Japan) for kindly providing the KAI3 cell line. We also thank Ms. H. Nakamura and Ms. M. Shiotani for their technical support. This work was supported by the Grants-in-Aid for Scientific Research from the Japan Society for the Promotion Science (JSPS) to T.O. [#22590312].

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article online at http://dx.doi.org/10.1080/10428194.2017.1304762

Additional information

Funding

This work was supported by the Grants-in-Aid for Scientific Research from the Japan Society for the Promotion Science (JSPS) to T.O. [#22590312].

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