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Leukemia & Lymphoma Volume 59, 2018 - Issue 1
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Original Articles: Clinical

Risk factors predicting the survival of pediatric patients with relapsed/refractory non-Hodgkin lymphoma who underwent hematopoietic stem cell transplantation: a retrospective study from the Turkish pediatric bone marrow transplantation registry

Volkan HazarDepartments of Pediatric Hematology and Oncology and BMT Unit, Medical Park Göztepe Hospital, Istanbul, Turkey; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-1407-2334
ORCID Icon,
Vural KesikGülhane Military Medical Academy, Ankara, Turkey;
,
Gülsün Tezcan KarasuFaculty of Medicine, Göztepe Medical Park Hospital, Bahçeşehir University, Istanbul, Turkey;
,
Gülyüz ÖztürkFaculty of Medicine, Acıbadem Atakent Hospital, Acıbadem UniversityIstanbul, Turkey;
,
Alphan KüpesizFaculty of Medicine, Akdeniz University, Antalya, Turkey;
,
Suar Çakı KılıçFaculty of Medicine, Göztepe Medical Park Hospital, Bahçeşehir University, Istanbul, Turkey;
,
Erman AtaşGülhane Military Medical Academy, Ankara, Turkey;
,
Vedat UygunFaculty of Medicine, Antalya Medical Park Hospital, Bahçeşehir University, Antalya, Turkey;
,
Nurşah EkerFaculty of Medicine, Akdeniz University, Antalya, Turkey;
,
Fatih ErbeyFaculty of Medicine, Acıbadem Atakent Hospital, Acıbadem UniversityIstanbul, Turkey;
,
Şebnem Yılmaz BengoaFaculty of Medicine, Dokuz Eylül University, Izmir, Turkey;
,
Suna EmirAnkara Child Health and Diseases Hematology Oncology Training and Research Hospital, Ankara, Turkey;
,
Sema AnakIstanbul Medical Faculty, Istanbul University, Istanbul, Turkey;
,
Haldun ÖnizTepecik Training and Research Hospital, Izmir, Turkey;
,
Hayriye DaloğluFaculty of Medicine, Antalya Medical Park Hospital, Bahçeşehir University, Antalya, Turkey;
,
Serap AksoylarFaculty of Medicine, Ege University, Izmir, Turkey;
,
Ülker KoçakFaculty of Medicine, Gazi University, Ankara, Turkey;
,
Musa KarakükçüFaculty of Medicine, Erciyes University, Kayseri, Turkey;
,
Murat ElliFaculty of Medicine, On Dokuz Mayıs University, Samsun, Turkey;
,
Nilgün KurucuAnkara Oncology Training and Research Hospital, Ankara, Turkey;
&
Akif YeşilipekFaculty of Medicine, Göztepe Medical Park Hospital, Bahçeşehir University, Istanbul, Turkey; ;Turkish Pediatric BMT Study Group, Istanbul, Turkey
 show all
Pages 85-96 | Received 01 Dec 2016, Accepted 01 May 2017, Published online: 02 Jun 2017
 
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Abstract

We examined outcomes of 62 pediatric patients with relapsed or refractory non-Hodgkin lymphoma (rr-NHL) who underwent hematopoietic stem cell transplantation (HSCT). The overall survival (OS) and event-free survival (EFS) rates were 65% and 48%, respectively. Survival rates for patients with chemosensitive disease at the time of HSCT were significantly higher than those of patients with chemoresistant disease (69% vs. 37%, p = .019 for OS; 54% vs. 12%, p < .001 for EFS; respectively). A chemoresistant disease at transplantation was the only factor that predicted a limited OS (hazard ratio = 10.00) and EFS (hazard ratio = 16.39) rates. Intensive chemotherapy followed by HSCT could be an effective strategy for treating children with rr-NHL and may offer improved survival for a significant group of pediatric patients, particularly those with chemosensitive disease at transplantation.

Acknowledgements

We acknowledge the support of American Journal Experts for English editing. We also acknowledge Özgür Tosun PhD from Near East University, Nicosia, Cyprus for assistance with statistical analyzes.

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article online at https://doi.org.10.1080/10428194.2017.1330472.

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