The diverse expression of the WT1 gene in patients with acquired bone marrow failure syndromes

Abstract

Acquired bone marrow failure syndromes (aBMFS) encompass a wide range of diseases. A study to investigate WT1 expression in BM was conducted in 387 patients with aBMFS in China. The WT1 level in patients with aplastic anemia (AA) was significantly lower than that in patients with paroxysmal nocturnal hemoglobinuria (PNH, p = .023) and myelodysplastic syndrome (MDS, p < .001). In addition, the WT1 level in patients with MDS significantly increased as the disease progressed to an advanced stage. Patients with hypoplastic MDS had a differentiated expression level of WT1 compared with that of NSAA (p < .001). Furthermore, post-treatment patients of AA with partial response (PR) or complete response (CR) status had relatively higher WT1 levels than those with naive AA (p = .017, p = .003, respectively). Thus, the WT1 expression level could be a useful genetic marker for routine clinical work in aBMFS.

Keywords:

• Anemia
• aplastic
• bone marrow failure
• WT1

Acknowledgements

The authors would like to thank all the doctors and nurses in the Therapeutic Centre of Anemic Diseases and the researcher team of the Clinical Laboratory Centre for their professional assistance.

This work was supported by grants from the National Natural Science Foundation of China [grant number: 81470289] and the Tianjin Municipal Science and Technology Commission [grant number: 16JCYBJC26200].

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article online at https://doi.org/10.1080/10428194.2017.1352092.

Additional information

Funding

This work was supported by grants from the National Natural Science Foundation of China [grant number: 81470289] and the Tianjin Municipal Science and Technology Commission [grant number: 16JCYBJC26200].