Lymphomas with kidney involvement: the French multicenter retrospective LyKID study

Abstract

The LyKID study is a nationwide survey in France of lymphoma patients with renal involvement based on biopsy and/or imaging, to evaluate its impact on disease outcome and renal function. A total of 87 adult cases of B or T-cell lymphomas were retrospectively analyzed. Interstitial topography was observed in most of the kidney biopsies (54/66; 80%). Kidney failure (glomerular filtration rate <60 mL/min/1.73 m²) was present in 47% of patients and was associated with non-significantly different outcome. After lymphoma treatment, 44% of patients had persistent chronic kidney failure (CKF); kidney failure at diagnosis was the only parameter associated with CKF in multivariate analysis. DLBCL (diffuse large B-cell lymphomas) represented half of the series, with noticeably CNS (central neurological system) relapse in 17% patients, while fewer than one of two patients had received CNS prophylaxis. To our knowledge, the LyKID study represents the largest published non-autopsy lymphoma series with renal involvement.

Keywords:

• Lymphoma
• chronic kidney failure
• prognostic factors
• central nervous system relapse
• diffuse large B cell lymphoma

Acknowledgments

The authors thank all the LYSA centers who were involved in the LyKID study, particularly the clinical research assistants who helped to collect the data and the scientific committee for their advice.

Disclosure statement

No potential conflict of interest was reported by the authors.