Advanced search
Publication Cover
Leukemia & Lymphoma Volume 61, 2020 - Issue 8
Submit an article Journal homepage
280
Views
3
CrossRef citations to date
0
Altmetric
Original Articles

Different MAF translocations confer similar prognosis in newly diagnosed multiple myeloma patients

Sarah Goldman-MazurDepartment of Hematology, Jagiellonian University Medical College, Cracow, Poland; Correspondence[email protected]
,
Artur JurczyszynDepartment of Hematology, Jagiellonian University Medical College, Cracow, Poland;
,
Jorge J. CastilloDana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; ORCID Iconhttp://orcid.org/0000-0001-9490-7532
ORCID Icon,
Anna Waszczuk-GajdaDepartment of Hematology, Oncology and Internal Diseases, Warsaw Medical University, Warsaw, Poland; ORCID Iconhttp://orcid.org/0000-0001-5626-1750
ORCID Icon,
Norbert GrząśkoDepartment of Experimental Hematology, Medical University of Lublin, Lublin, Poland; ;Department of Hematology, St. John’s Cancer Center, Lublin, Poland;
,
Jakub Radocha4th Department of Internal Medicine – Hematology, University Hospital, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic;
,
Max BittrichDepartment of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany;
,
Klaus Martin KortümDepartment of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany; ORCID Iconhttp://orcid.org/0000-0002-7011-0286
ORCID Icon,
Alessandro GozzettiDivision of Hematology, Department of Medical Science, Surgery and Neuroscience, University of Siena, Siena, Italy;
,
Lidia Usnarska-ZubkiewiczDepartment of Hematology, Wroclaw Medical University, Wroclaw, Poland;
,
Julio D. VallsComplejo Asistencial de Avila, Avila, Spain;
,
David S. JayabalanWeill Cornell Medical College, New York, NY, USA;
,
Ruben NiesvizkyWeill Cornell Medical College, New York, NY, USA;
,
Julia KelmanWeill Cornell Medical College, New York, NY, USA;
,
Daniel CoriuDepartment of Hematology, Fundeni Clinical Institute, University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania; ORCID Iconhttp://orcid.org/0000-0002-7251-6079
ORCID Icon,
Laura RosiñolDepartments of Hematology, Amyloidosis and Myeloma Unit, Hospital Clínic, IDIBAPS, University of Barcelona, Barcelona, Spain; ORCID Iconhttp://orcid.org/0000-0001-9531-961X
ORCID Icon,
Łukasz SzukalskiDepartment of Hematology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland;
,
Veronica González-CalleHospital Universitario de Salamanca/Instituto Biosanitario de Salamanca (IBSAL), Salamanca, Spain;
,
María-Victoria MateosHospital Universitario de Salamanca/Instituto Biosanitario de Salamanca (IBSAL), Salamanca, Spain; ORCID Iconhttp://orcid.org/0000-0003-2390-1218
ORCID Icon,
Krzysztof JamroziakInstitute of Hematology and Transfusion Medicine, Warsaw, Poland;
,
Iwona HusDepartment of Experimental Hematology, Medical University of Lublin, Lublin, Poland; ;Department of Hematology, St. John’s Cancer Center, Lublin, Poland; ;Institute of Hematology and Transfusion Medicine, Warsaw, Poland;
,
Irit AviviTel Aviv Sourasky Medical Center, Tel Aviv, Israel and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;
,
Yael CohenTel Aviv Sourasky Medical Center, Tel Aviv, Israel and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; ORCID Iconhttp://orcid.org/0000-0002-9061-7287
ORCID Icon,
Piotr MazurInstitute of Cardiology, Jagiellonian University Medical College, Cracow, Poland; ORCID Iconhttp://orcid.org/0000-0003-4077-1232
ORCID Icon,
Anna SuskaDepartment of Hematology, Jagiellonian University Medical College, Cracow, Poland;
,
Aimee ChappellDepartment of Hematology/Oncology, Medstar Georgetown University Hospital, Washington, NW, USA;
,
Deepu MadduriIcahn School of Medicine at Mount Sinai, Tisch Cancer Institute, New York, NY, USA;
,
Saurabh ChhabraDivision of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA;
,
Ariel KlemanDivision of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA;
,
Parameswaran HariDivision of Hematology/Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA;
,
Michel DelforgeDepartment of Hematology, UZ Leuven, Leuven, Belgium;
,
Paweł RobakDepartment of Experimental Hematology, Medical University of Lodz, Lodz, Poland;
,
Massimo GentileHematology Unit, AO Cosenza, Cosenza, Italy;
,
Izabela KozłowskaDepartment of Hematology, SPZOZ ZSM, Chorzow, Poland;
,
Stuart L. GoldbergJohn Theurer Cancer Center, Hackensack UMC, Hackensack, NJ, USA; ;Cota Inc, Boston, MA, USA;
,
Jacek CzepielDepartment of Infectious and Tropical Diseases, Jagiellonian University Medical College, Cracow, Poland;
,
Monika Długosz-DaneckaMaria Sklodowska-Curie National Institute of Oncology, Cracow, Poland; ORCID Iconhttp://orcid.org/0000-0002-8927-4125
ORCID Icon,
Rebecca SilbermannDivision of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA;
,
Adam J. OlszewskiDepartment of Medicine, Warren Alpert Medical School, Brown University, Providence, RI, USA; ORCID Iconhttp://orcid.org/0000-0002-6472-6658
ORCID Icon,
Peter BarthDepartment of Medicine, Warren Alpert Medical School, Brown University, Providence, RI, USA;
,
Gabor MikalaDepartment of Hematology and Stem Cell Transplantation, South-Pest Central Hospital, National Institute of Hematology and Infectology, Budapest, Hungary;
,
Chor S. ChimDepartment of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, Hong KongORCID Iconhttp://orcid.org/0000-0003-2427-915X
ORCID Icon &
David H. VesoleJohn Theurer Cancer Center, Hackensack UMC, Hackensack, NJ, USA;
show all
Pages 1885-1893 | Received 29 Jan 2020, Accepted 24 Mar 2020, Published online: 19 Apr 2020
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Abstract

The MAF translocations, t(14;16) and t(14;20), are considered as adverse prognostic factors based on few studies with small sample sizes. We report on their prognostic impact in a large group of 254 patients – 223 (87.8%) with t(14;16) and 31 (12.2%) with t(14;20). There were no intergroup differences in survival estimates. Median progression-free survival was 16.6 months for t(14;16) and 24.9 months for t(14;20) (p = 0.28). Median overall survival (OS) was 54.0 months and 49.0 months, respectively (p = 0.62). Median OS in patients who underwent double autologous stem cell transplantation (ASCT) was 107.0 months versus 60.0 months in patients who received single ASCT (p < 0.001). ISS 3 was associated with shorter OS (HR = 1.89; 95% CI 1.24–3.19; p = 0.005) in Cox analysis. Our study suggests that t(14;20) should be considered as an adverse factor of equal prognostic implication to t(14;16).

Acknowledgments

The authors expressed their gratitude for all persons who were involved in reporting patients and gathering data.

Disclosure statement

The authors declare no conflict of interests.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,065.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.