Acknowledgements
Dr. O’Connor is recipient of the American Cancer Society Research Professorship.
Authorship contributions
AS, HM and OAO wrote the manuscript. BC performed the statistical analysis. AS, CD, KJS, DV, MC, JMC, and OAO provided cases. All authors critically analyzed the data, reviewed the manuscript and contributed to the final version.
Disclosure statement
DV has received honoraria from Seattle Genetics, Lundbeck, Abbvie, Celgene, Janssen, AstraZeneca, Roche, and Nanostring. JMC received research support and honoraria from Seattle Genetics and Takeda Pharmaceuticals. OAO received research support from Spectrum, Celgene, Merck, Affimed, Seattle Genetics, and Scientific Advisory Role with Mundipharma. All other authors declare no competing interests.