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Leukemia & Lymphoma Volume 63, 2022 - Issue 8
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Letters to the Editor

Infusion of haploidentical NKG2D-CAR-TCD45RA- cells in two pediatric patients with advanced relapsed and refractory acute leukemia was safe but achieved no clinical benefits

Adrián Fernándeza Hematological Malignancies Lab-H12O Clinical Research Unit, Spanish National Cancer Research Center (CNIO), Madrid, SpainView further author information
,
Antonio Pérez-Martínezb Pediatric Hemato-Oncology Department, La Paz University Hospital, Madrid, Spain;c Translational Research Group in Pediatric Oncology Hematopoietic Transplantation and Cell Therapy, La Paz University Hospital Institute for Health Research-IdiPAZ, Madrid, Spain;d Pediatric Department, Autonomous University of Madrid, Madrid, SpainCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-6436-9195View further author information
ORCID Icon,
Adela Escuderoe Pediatric Molecular Hemato-Oncology Department, Medical and Molecular Genetics Institute (INGEMM), La Paz University Hospital, Madrid, SpainORCID Iconhttps://orcid.org/0000-0001-8101-4014View further author information
ORCID Icon,
Isabel Mironesf Advanced Therapy Medicinal Products Production Unit, Pediatric Hemato-Oncology Service and Pharmacy Service, La Paz University Hospital, Madrid, SpainView further author information
,
Berta Gonzálezb Pediatric Hemato-Oncology Department, La Paz University Hospital, Madrid, SpainView further author information
,
Raquel de Pazg Hematology and Hemotherapy Department, La Paz University Hospital, Madrid, SpainView further author information
,
Nerea Matamalae Pediatric Molecular Hemato-Oncology Department, Medical and Molecular Genetics Institute (INGEMM), La Paz University Hospital, Madrid, SpainView further author information
,
Laura Claresc Translational Research Group in Pediatric Oncology Hematopoietic Transplantation and Cell Therapy, La Paz University Hospital Institute for Health Research-IdiPAZ, Madrid, SpainView further author information
,
Alfonso Navarroc Translational Research Group in Pediatric Oncology Hematopoietic Transplantation and Cell Therapy, La Paz University Hospital Institute for Health Research-IdiPAZ, Madrid, SpainView further author information
,
Victor Galánb Pediatric Hemato-Oncology Department, La Paz University Hospital, Madrid, SpainORCID Iconhttps://orcid.org/0000-0002-2682-9664View further author information
ORCID Icon,
Isabel Martínez-Romerab Pediatric Hemato-Oncology Department, La Paz University Hospital, Madrid, SpainView further author information
,
Joaquín Martínez-Lópeza Hematological Malignancies Lab-H12O Clinical Research Unit, Spanish National Cancer Research Center (CNIO), Madrid, Spain;h Hematology Department, 12 de Octubre University Hospital, Madrid, SpainORCID Iconhttps://orcid.org/0000-0001-7908-0063View further author information
ORCID Icon,
Alejandra Leivasa Hematological Malignancies Lab-H12O Clinical Research Unit, Spanish National Cancer Research Center (CNIO), Madrid, Spain;h Hematology Department, 12 de Octubre University Hospital, Madrid, SpainView further author information
,
Mar Valés-Gómezi Tumor Immune Activation and Evasion Group, National Biotechnology Center, Madrid, SpainView further author information
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Cristina Ferrerasc Translational Research Group in Pediatric Oncology Hematopoietic Transplantation and Cell Therapy, La Paz University Hospital Institute for Health Research-IdiPAZ, Madrid, SpainView further author information
&
Lucía Fernándeza Hematological Malignancies Lab-H12O Clinical Research Unit, Spanish National Cancer Research Center (CNIO), Madrid, SpainView further author information
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Pages 1970-1974 | Received 16 Dec 2021, Accepted 19 Mar 2022, Published online: 03 Apr 2022
 
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Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the National Health Service of Spain, Carlos III Health Institute (ISCIII), FONDOS FEDER grant (FIS) PI18/01301 and ICI19/00052 to Pérez-Martínez A, Galán V, CRIS Foundation to Beat Cancer to Ferreras C, Fernández A, Fernández L, Mirones I, and Fundación Unoentrecienmil (2017); Madrid Regional Government ‘IMMUNOTHERCAN’ [S2017/BMD-3733-2 (Valés-Gómez)]; the Spanish Ministry of Science and Innovation [(MCIU/AEI/FEDER, EU): RTI2018-093569-B-I00 (Valés-Gómez)].

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