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Leukemia & Lymphoma Volume 64, 2023 - Issue 1
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Letters to the Editor

Detection of constitutional mismatch repair deficiency in children and adolescents with acute lymphoblastic leukemia

Richard Gallona Translational and Clinical Research Institute, Newcastle University, Newcastle-upon-Tyne, UKCorrespondence[email protected]
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Rachel Phelpsa Translational and Clinical Research Institute, Newcastle University, Newcastle-upon-Tyne, UKView further author information
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Leigh Bettsa Translational and Clinical Research Institute, Newcastle University, Newcastle-upon-Tyne, UKView further author information
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Christine Hayesa Translational and Clinical Research Institute, Newcastle University, Newcastle-upon-Tyne, UKView further author information
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Dino Masica Translational and Clinical Research Institute, Newcastle University, Newcastle-upon-Tyne, UKView further author information
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Julie A. E. Irvinga Translational and Clinical Research Institute, Newcastle University, Newcastle-upon-Tyne, UKView further author information
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Ciaron McAnultyb Northern Genetics Service, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, UKView further author information
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Vaskar Sahac Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK;d Tata Translational Cancer Research Centre, Tata Medical Center, Kolkata, IndiaView further author information
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Ajay Vorae Department of Paediatric Haematology, Great Ormond Street Hospital, London, UKView further author information
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Katharina Wimmerf Institute of Human Genetics, Medical University of Innsbruck, Innsbruck, AustriaView further author information
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Jayashree Motwanig Department of Haematology, Birmingham Women’s and Children’s Hospital, Birmingham, UKView further author information
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Christine Macartneyh Department of Paediatric Haematology and Oncology, Royal Belfast Hospital for Sick Children, Belfast, UKView further author information
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John Burna Translational and Clinical Research Institute, Newcastle University, Newcastle-upon-Tyne, UKView further author information
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Michael S. Jacksoni Biosciences Institute, Newcastle University, Newcastle-upon-Tyne, UKView further author information
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Anthony V. Moormana Translational and Clinical Research Institute, Newcastle University, Newcastle-upon-Tyne, UKView further author information
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Mauro Santibanez-Korefi Biosciences Institute, Newcastle University, Newcastle-upon-Tyne, UKView further author information
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Pages 217-220 | Received 23 May 2022, Accepted 20 Sep 2022, Published online: 22 Oct 2022
 
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Acknowledgements

The authors thank Cancer Research UK for funding this study through their Catalyst Award (C569/A24991) and the UKALL clinical trial organisers and participants for providing the necessary material to conduct this study. The authors also thank the diagnostic services and patients who provided additional control material.

Disclosure statement

RG, JB, MSJ, and MSK are named as inventors, and CH is named as a contributor, on patents covering the markers used in the microsatellite instability assay used in this study (WO/2018/037231, published March 1, 2018; WO/2021/019197, published February 4 2021).

Data availability statement

Amplicon sequence data .fastq files are available from the European Nucleotide Archive using Study ID PRJEB51926.

Additional information

Funding

This work was supported by the Cancer Research UK Catalyst Award under Grant C569/A24991.

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