Anti-plasmodial Activity of the Mixed Stem Bark Extracts of Anogeissus leiocarpus and Prosopis africana and in vitro Evaluation of Its Tablet Dosage Form

Abstract

The antinociceptive, immunostimulatory, and antiplasmodial properties of Anogeissus leiocarpus and Prosopis africana combined aqueous extract (AA1) and its single tablet formulation were evaluated. Results showed that AA1 suppressed parasitaemia in early infection by 50% and 69% at 200 and 400 mg.kg⁻¹ body weight (b.w) respectively. In established infection, AA1 reduced parasitaemia by 55% to 78% at 100 to 400 mg.kg⁻¹ b.w. Dissolution results show that the tablets formulated with 10% disintegrant released 90% of the drug in less than 30 min, proving to be suitable in acute malaria attack.

Keywords:

• antimalarial
• medicinal plants
• mixed herbal formulation