Advanced search
Publication Cover
Biotechnic & Histochemistry Volume 96, 2021 - Issue 5
Submit an article Journal homepage
309
Views
0
CrossRef citations to date
0
Altmetric
Articles

Activation of cannabinoid 2 receptors by JWH-133 protects against ovarian ischemia-reperfusion injury in rats

Taylan Onata Department of Obstetrics and Gynecology, Faculty of Medicine, Yozgat Bozok University, Yozgat, TurkeyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-8920-1444View further author information
ORCID Icon,
Melike Demir Caltekina Department of Obstetrics and Gynecology, Faculty of Medicine, Yozgat Bozok University, Yozgat, TurkeyORCID Iconhttps://orcid.org/0000-0001-8797-7794View further author information
ORCID Icon,
Züleyha Doğanyigitb Department of Histology-Embryology, Faculty of Medicine, Yozgat Bozok University, Yozgat, TurkeyORCID Iconhttps://orcid.org/0000-0002-6980-3384View further author information
ORCID Icon,
Can Turklerc Department of Obstetrics and Gynecology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, TurkeyORCID Iconhttps://orcid.org/0000-0003-2716-0322View further author information
ORCID Icon,
Emin Kaymakb Department of Histology-Embryology, Faculty of Medicine, Yozgat Bozok University, Yozgat, TurkeyORCID Iconhttps://orcid.org/0000-0002-3818-2693View further author information
ORCID Icon,
Mustafa Karad Department of Obstetrics and Gynecology, Medical Faculty, Ahi Evran University, Kirsehir, TurkeyORCID Iconhttps://orcid.org/0000-0003-2282-6850View further author information
ORCID Icon &
Ethem Serdar Yalvaca Department of Obstetrics and Gynecology, Faculty of Medicine, Yozgat Bozok University, Yozgat, TurkeyORCID Iconhttps://orcid.org/0000-0001-9941-4999View further author information
ORCID Icon show all
Pages 394-400 | Published online: 12 Apr 2021
 
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

ABSTRACT

We investigated the efficacy of activated cannabinoid 2 receptors for alleviating ovarian ischemia-reperfusion injury in rats. Female Wistar albino rats were divided randomly into six groups: ischemia-reperfusion (IRG); ischemia-reperfusion + 0.2 mg/kg JWH-133 (JIRG1), ischemia-reperfusion + 1 mg/kg JWH-133 (JIRG2); ischemia-reperfusion + 5 mg/kg JWH-133 (JIRG3); solvent control, and sham control. Ovarian ischemia was established for 3 h followed by reperfusion for 3 h. Ovarian tissue was investigated using histology, immunohistochemistry and biochemistry. Administration of JWH-133 synthetic cannabinoid reduced nuclear factor kappa-B immunoreactivity as well as TUNEL positivity scores and malondialdehyde levels. These reductions were significant in all cases except for the malondialdehyde levels in the 1 mg/kg JWH-133 group. Activation of cannabinoid 2 receptors by JWH-133 reduced ovarian ischemia-reperfusion injury due to its antioxidant and anti-inflammatory effects.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This study was supported by the Yozgat Bozok University Project Coordination Application and Research Center [6602c-TF/19-249].

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 203.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.