Abstract
A previous study has suggested that sensitization to the psychosis-inducing effects of cocaine may be a marker of vulnerability to relapse in cocaine addiction. In this report, cocaine-dependent subjects participating in a study on naturally occurring and cue-induced cocaine craving were interviewed about prior experience of cocaine-induced psychosis and the degree to which this effect had become more frequent or severe or had occurred at lower cumulative doses. Sensitization to cocaine-induced psychosis was negatively correlated with baseline measures of drug dependence severity and indices of cocaine craving over the preceding 24 hours but not with measures of cocaine cue reactivity. (Am J Addict 2004;13:305–315)
Notes
From the Department of Psychiatry, New York University School of Medicine, New York, NY (Drs. Reid and Angrist, Ms. Ciplet and Ms. O'Leary); and the Department of Psychiatry, State University of New York—Health Science Center at Brooklyn, Brooklyn, NY (Drs. Branchey and Buydens-Branchey).
*Interviewer administered assessment
†Sensitization to cocaine-induced paranoia was quantified for each subject using items from question 4.