Ability of simple organotin polyethers to inhibit pancreatic cancer

ABSTRACT

A wide variety of organotin polyethers derived from the interfacial polymerization of dibutyltin dichloride and non-cancer inhibitory diols show decent to good inhibition of two human pancreatic cancer cell lines. In view of the general lack of ability of tested compounds to inhibit pancreatic cancer cell lines, this is significant. These cell lines are the AsPC-1 pancreatic cancer cell line which is an adenocarcinoma pancreatic cell line and the PANC-1 pancreatic cancer cell line which is an epithelioid carcinoma pancreatic cell line. The dibutyltin polyethers generally both exhibit EC₅₀ values in the same range and lower than cisplatin and higher CI₅₀ values than cisplatin. Essentially all of the polymers derived from simple non-aromatic diols showed CI₅₀ values greater than 2.

KEYWORDS:

• Anticancer drug
• AsPC-1 cell line
• interfacial polycondensation
• organotin polymers
• PANC-1 pancreatic cancer cell line, tin-containing polymer
• pancreatic cancer