Lipid-coated calcium phosphate nanoparticle and beyond: a versatile platform for drug delivery

Abstract

In recent years, lipid-coated calcium-phosphate (LCP) nanoparticle has been developed as a versatile platform for delivery of various therapeutics including gene, protein/peptide, chemotherapeutics and theranostic agents. The high endosomal escape, coupled with the ability to efficiently encapsulate phosphorylated drugs or prodrugs, make LCP become attractive vehicle for drug delivery. Additionally, the principle behind LCP formulation has also allowed rational design of LCP-derived nanoparticles (NPs) with other solid core or lipid membrane to overcome the various drug delivery barriers. Here, we briefly review the history of the development of LCP NPs, highlight the optimisations and modulations in the development process, and summarise the major applications of LCP NPs and LCP-derived NPs in drug delivery.

Keywords:

• Liposome
• calcium phosphate
• lipid-coated calcium-phosphate nanoparticles
• endosomal escape
• reconstituted high-density lipoprotein
• drug delivery

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

Additional information

Funding

This work was supported by National Natural Science Foundation of China [No. 81373351, 81573382 and 81722043], grant from Shanghai Science and Technology Committee [15540723700], and ‘Shu Guang’ project supported by Shanghai Municipal Education Commission and Shanghai Education Development Foundation [15SG14].