Interleukin-1β and uric acid as potential second-trimester predictive biomarkers of preeclampsia

ABSTRACT

Methods: The prospective study was conducted at the University Hospital from February 2020 to December 2020. The study population (n = 88) included women who later developed PE (n = 42), as well as women who were healthy at birth (n = 46) in the second trimester of pregnancy. Serum levels of CRP, IL-1β, uric acid, creatinine, AST, ALT, MPV, Hb, PC, vitamin D, Ca, and Mg were compared between the groups.

Results: Serum IL-1β and uric acid levels were significantly higher in subjects who eventually developed PE compared with those who did not.

Conclusions: IL-1β and uric acid may be a predictive markers for PE. Maternal serum IL-1β and uric acid levels in the second trimester of pregnancy may be a predictive markers for PE.

KEYWORDS:

• Preeclampsia
• CRP
• interleukin-1β
• uric acid
• MPV
• vitamin D
• calcium
• magnesium

Acknowledgments

There are no acknowledgments or fundings to declare.

Author Contributions

Concept – K.D, A.K; Design- K.D, A.K; Supervision- K.D, A.K M.D; Materials – K.D, A.K, Y.O; Data Collection and/or Processing – K.D, A.K, Y.O; Analysis and/or Interpretation – K.D; Literature Review – K.D; Writing - K.D, Critical Review - K.D, A.K, M.D

Ethics Committee Approval

Ethics committee approval was received for this study from the Clinical Research Ethics Committee of Istanbul Teaching and Research Hospital.

Disclosure statement

The authors declared that this study has received no financial support.

Peer-review

Externally peer-reviewed.