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Clinical and Experimental Hypertension Volume 30, 2008 - Issue 7
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A Pilot Study on Level of Blood Vasoactive Factors in Prehypertensive and Hypertensive Patients

ZuoGuang Wang Division of Hypertension, Beijing Institute of Heart, Lung, Blood Vessel Diseases, Beijing Anzhen Hospital, Attached to Capital University of Medical Sciences, Beijing, P. R. China
,
Ya Liu Division of Hypertension, Beijing Institute of Heart, Lung, Blood Vessel Diseases, Beijing Anzhen Hospital, Attached to Capital University of Medical Sciences, Beijing, P. R. China
,
JieLing Liu Division of Hypertension, Beijing Institute of Heart, Lung, Blood Vessel Diseases, Beijing Anzhen Hospital, Attached to Capital University of Medical Sciences, Beijing, P. R. China
,
Jie Wen Division of Hypertension, Beijing Institute of Heart, Lung, Blood Vessel Diseases, Beijing Anzhen Hospital, Attached to Capital University of Medical Sciences, Beijing, P. R. China
,
ShaoJun Wen Division of Hypertension, Beijing Institute of Heart, Lung, Blood Vessel Diseases, Beijing Anzhen Hospital, Attached to Capital University of Medical Sciences, Beijing, P. R. ChinaCorrespondence[email protected]
&
ZhaoSu Wu Division of Epidemiology, Beijing Institute of Heart, Lung, Blood Vessel Diseases, Beijing Anzhen Hospital, Attached to Capital University of Medical Sciences, Beijing, P. R. China
Pages 598-605 | Received 06 Nov 2007, Accepted 02 Apr 2008, Published online: 03 Jul 2009
 
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Abstract

A pilot study was conducted to investigate blood pressure level and vasoactive factors (VFs) among age- and sex-matched normotensive (NT), prehypertensive (PH), and hypertensive (EH) subjects. The results showed that angiotensin, arginine vasopressin, and endothelin were significantly higher, while adrenomedullin and calcitonin gene-related peptide were lower in the EH group than in the PH and NT groups. Nitric oxide synthase was not different among the three groups. There was a dose-response relationship between VFs and BP status. The results suggested that changes in blood VFs might be early warning signs of the development of prehypertension to hypertension, and important biomarkers for the early prevention of prehypertension.

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