Association between CYP3A5 genotypes with hypertension in Chinese Han population: A case-control study

ABSTRACT

Background: The association of CYP3A5 gene polymorphisms with hypertension in the Chinese population is unknown. We explored the association between the CYP3A5 (rs776746) gene and hypertension in the Chinese Han population. Methods: Using a case-control design, 340 cases and 254 controls were enrolled from the Third Affiliated Hospital of South Medical University between July and December of 2015. We used a standardized questionnaire to collect data regarding age, sex, smoking, drinking, family history of hypertension, and physical exercise. Height and weight were measured, and the body mass index (BMI) was calculated by weight/height². Blood pressure was measured three times after 5 min of rest with at least 15 s between measurements, and the mean was considered the final BP. A Clinical examination was conducted. Results: A total of 594 participants, including 340 cases and 254 controls, were entered into the analyses. The genotype frequencies of the CYP3A5 G>A polymorphism did not deviate from the Hardy-Weinberg equilibrium. The genotype frequencies among the cases were 38.8% (GA, 132 individuals), 42.9% (GG, 146 individuals), and 18.2% (AA, 62 individuals). The differences in genotype between the cases and the controls were statistically significant. The AA genotype was associated with an elevated risk of hypertension after adjusting for potential confounders in Model 2. There was no interaction between smoking and the CYP3A5 genotype, while the interaction between drinking and the CYP3A5 genotype was significant. Conclusion: The CYP3A5 gene may be associated with the risk of hypertension in the Chinese Han population, and this effect may be exacerbated by drinking.

KEYWORDS:

• Case-control
• CYP3A5 gene
• gene polymorphism
• hypertension
• interaction

Acknowledgments

ZZL and LZC conceived and designed the experiments. ZZL, TZ, and XFC participated in the design of the study and performed the statistical analysis. ML and PC conceived of the study, participated in its design and coordination, and helped to draft the manuscript. All authors read and approved the final manuscript.

Conflict of interest

The authors report no conflicts of interest.

Funding

Hunan Province Science and Technology Project (2014SK2013), fundamental research funds for the central universities of Central South University (2014zzts069), and Graduate Innovation Project of Hunan Province (CX2014B097).

Additional information

Funding

Hunan Province Science and Technology Project (2014SK2013), fundamental research funds for the central universities of Central South University (2014zzts069), and Graduate Innovation Project of Hunan Province (CX2014B097).