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ABSTRACT
Background: Few studies had examined the role of ABO blood groups on CAD in hypertensive patients with different blood pressure (BP) controls. Methods: A total of 2708 patients with primary hypertension (HTN) were consecutively enrolled and underwent coronary angiography (CAG) due to angina-like chest pain. The severity of coronary artery stenosis was assessed by Gensini score (GS). Patients were divided into two groups due to results of CAG: HTN with CAD (n = 2185) and HTN without CAD (n = 523). Poor BP control was defined as systolic BP (SBP) ≥ mean in the study. Multivariable regression analysis was used to determine the potential impact of ABO blood groups on risk of the presence and severity of CAD. Results: Compared to HTN without CAD group, the percentage of A blood group was statistically higher and O blood group was significantly lower in HTN with CAD group. Moreover, percentage of the angiography-proven CAD was higher in A blood group than that in non-A blood group (p < 0.05). After adjusting for confounding factors, A blood group was independently associated with CAD (odds ratio (OR): 1.422; 95% confidence interval (CI): 1.017–1.987; p = 0.039) and GS (β = 0.055, p = 0.046) in patients with poor BP control. Conclusions: A blood group was an independent risk factor for the presence and severity of CAD in hypertensive patients with poor BP control.
Declaration of interest
The authors declare that they have no conflict of interest.
Funding
This study was partly supported by the National Natural Scientific Foundation (81241121), Capital Special Foundation of Clinical Application Research (Z121107001012015), Capital Health Development Fund (2011400302) and Beijing Natural Scientific Foundation (7131014) awarded to Dr. Jianjun Li, MD, PhD.