The ALDH2 gene rs671 polymorphism is not associated with essential hypertension

ABSTRACT

Essential hypertension (EH) is a worldwide problem. Acetaldehyde dehydrogenase 2 (ALDH2) gene has been suggested to be correlated with EH. However, the results are inconsistent. This study aimed to investigate the associations of ALDH2 rs671 polymorphism with EH in a Chinese Han population in Shanghai. Genotype of ALDH2 rs671 was analyzed in 1923 EH patients and 1115 control subjects. We found no association between ALDH2 rs671 and EH risk or EH-related quantitative blood chemistry values. Furthermore, a meta-analysis was performed and the summary results from 11220 patients and 8339 control subjects were consistent with our findings. These results indicated that rs671 of ALDH2 may not associate with the risk of EH.

KEYWORDS:

• ALDH2
• essential hypertension
• obesity
• rs671
• SNP

Declaration of interest

The authors declare that they have no conflict of interest.

Funding

This work is supported by grants from National Natural Science Foundation of China (grant numbers 81472758, U1302225, and 31170783).

Additional information

Funding

This work is supported by grants from National Natural Science Foundation of China (grant numbers 81472758, U1302225, and 31170783).