Influence of PRKCH gene polymorphism on antihypertensive response to amlodipine and telmisartan

ABSTRACT

This study aimed to evaluate the effect of PRKCH rs2230500 genetic polymorphism on efficacy of amlodipine and telmisartan for patients with hypertension. A total of 136 essential hypertension (EH) patients were treated with amlodipine (70 patients) or telmisartan (66 patients), respectively. Genetic polymorphism was genotyped by Sanger sequencing. Both baseline and post-treatment blood pressure (BP) and heart rate were measured to evaluate the influence of genetic polymorphism on the antihypertensive response. No significant difference in the absolute decrease in diastolic blood pressure (DBP),systolic blood pressure (SBP), and mean arterial pressure (MAP) was observed among PRKCH rs2230500 genotypes after 4-week amlodipine or telmisartan therapy (p > 0.05). However, when compared with carriers or GG genotype, the antihypertensive effect of PRKCH rs2230500 GA/AA carriers was superior in telmisartan treatment group. PRKCH rs2230500 gene polymorphism is significantly related to the efficiency in telmisartan therapy (p = 0.02). The PRKCH rs2230500 may influence the antihypertensive efficacy of telmisartan in Chinese EH patients, and further studies are needed to confirm these findings.

KEYWORDS:

• Amlodipine
• antihypertensive response
• genetic polymorphisms
• PRKCH
• telmisartan

Conclusions

In conclusion, our results showed that the PRKCH rs2230500 affects the antihypertensive response after telmisartan therapy but not amlodipine therapy in Chinese EH patients.

Acknowledgments

The authors are grateful to the study participants.

Declaration of interest

The authors declare no conflict of interest.