Blood pressure goal for the elderly Chinese: the findings from the Northern Shanghai Study

ABSTRACT

Background: The Eighth Joint National Committee Panel (JNC8) recommended a novel blood pressure (BP) goal for individuals with hypertension, which was less stringent than the Seventh Joint National Committee (JNC7) guideline and is still under debate. In our study, we aimed at finding a better BP goal for the elderly Chinese. Methods: About 1599 community-based elderly participants were recruited in the northern Shanghai and were classified by chronic kidney disease or diabetes mellitus to investigate their BP control conditions based on both the JNC7 and JNC8. Then, participants were categorized into four groups: normotensive individuals (Group 1), individuals at BP goal by JNC7 (Group 2), individuals at BP goal by JNC8 but not by JNC7 (Group 3), and individuals not at-goal by both guidelines (Group 4). Patients’ hypertensive target organ damages as left ventricular mass index (LVMI), peak transmitral pulsed Doppler velocity/early diastolic tissue Doppler velocity (E/Ea), pulse wave velocity (PWV), etc. were evaluated. Results: According to the JNC8, 19.0% of the population were reclassified as at-goal. Group 4 had significantly greater LVMI than Group 2 (96.5 vs 91.5 g/m², p < 0.05) and also had significantly greater E/Ea (10.3 vs 9.7 and 10.3 vs 9.7, p < 0.05) and PWV (10.3 vs 9.3 m/s and 10.3 vs 9.7 m/s, p < 0.05) than both Group 2 and Group 3; however, there were no significant differences of these variables between Group 2 and Group 3. Conclusion: In the community-based elderly Chinese, the JNC8 hypertension guideline may set a better BP goal than the JNC7 in identifying patients’ left ventricular diastolic dysfunction and arterial stiffening.

KEYWORDS:

• Blood pressure
• elderly Chinese
• guidelines
• hypertension
• target organ damage

Conflict of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Acknowledgments

We thank all the investigators and subjects who participated in the NSS.

Funding

This study was authorized and financially supported by the Shanghai municipal government (Grant ID, 2013ZYJB0902; 15GWZK1002). Dr. Yi Zhang was supported by the National Nature Science Foundation of China (Grant ID. 81300239; 81670377).

Supplemental material

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Additional information

Funding

This study was authorized and financially supported by the Shanghai municipal government (Grant ID, 2013ZYJB0902; 15GWZK1002). Dr. Yi Zhang was supported by the National Nature Science Foundation of China (Grant ID. 81300239; 81670377).