Association study of polymorphisms of endoplasmic reticulum aminopeptidase 1 gene with preeclampsia in Chinese populations

ABSTRACT

Objective

To explore the correlation of polymorphisms of endoplasmic reticulum aminopeptidase-1 (ERAP-1) gene in Chinese women with preeclampsia.

Method

In this case–control study, 51 severely preeclamptic and 48 healthy pregnant women were retrospectively involved in Beijing Obstetrics and Gynecology Hospital from October 2017 to October 2019. The venous blood and umbilical cord blood were collected to analyze different single nucleotide polymorphisms (SNPs) in ERAP-1 gene in both groups.

Result

We firstly screened nine SNPs that were significantly different between two groups (P< .1) via univariate analysis. Pearson Chi-Square Test and Fisher’s Exact Test were performed to verify the correlation of SNPs with preeclampsia. Finally, genotype TC located in 96121524 position was associated with an increased risk of preeclampsia (P= .020, OR = 2.002, 95% CI: 0.687–5.831).

Conclusion

There might be a correlation between polymorphism of 96121524 in ERAP-1 gene and preeclampsia susceptibility in pregnant women of Han nationality in Beijing.

KEYWORDS:

• Endoplasmic reticulum aminopeptidase-1
• preeclampsia
• Chinese women
• single nucleotide polymorphisms

Acknowledgments

None.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Contributions

CM and WZ designed the study. CM, YZ and XL collected and analyzed the data. CM and YZ drafted and wrote the manuscript. XL and WZ revised the manuscript critically for intellectual content. All authors gave intellectual input to the study and approved the final version of the manuscript.

Ethics declarations

Ethics approval and consent to participate

The study was approved by the Ethics Committee of Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University (NO. 2019-KY-0301). All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Written informed consent was obtained from every participant.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Additional information

Funding

This study was supported by the National Key Research and Development Program of China (No. 2016YFC1000403).