Biocompatibility of a magnesium coating on a titanium surface and its effects on BMSCs

ABSTRACT

Surface modification can effectively improve the biological activity of Ti, which is currently a popular research topic. In this study, we applied plasma electrolytic oxidation (PEO) technology to prepare a porous Mg-TiO₂ coating on the surface of a Ti sheet. Then, we observed the adhesion and proliferation of bone marrow mesenchymal stem cells (BMSCs) on the surface of the Mg-TiO₂ coating. The results showed that the Mg-TiO₂ coating had a porous structure, and there was a uniform distribution of Mg on the surface and in the pores of the coating. The porous Mg-TiO₂ coating showed good cytocompatibility and no obvious cytotoxicity. Significantly more BMSCs adhered to and proliferated on its surface than on pure Ti (p < 0.05). In conclusion, a Mg-TiO₂ coating with a good surface morphology and good biocompatibility and bioactivity was prepared on a Ti surface by plasma technology and may have potential for clinical applications.

KEYWORDS:

• Titanium
• coating
• bone marrow mesenchymal stem cells
• biocompatibility
• bioactivity

Acknowledgments

This work was supported by the Wuxi Municipal Health Commission Youth Project under Grant Q202046, Medical and Health High-level Talents of Wuxi “Taihu Talent Plan”, General Program of Jiangsu Health Committee under Grant M2020008, Key R&D Program of Jiangsu Province under Grant BE2021683, Scientific Research Projects of Wuxi Health Committee under Grants M202040 and 2020ZHYB09, Guizhou Provincial Science and Technology Projects under Grant ZK[2022]-267 and General Program of Guizhou Health Committee under Grant gzwkj2021-231.

Disclosure statement

No potential conflict of interest was reported by the author(s).