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Abstract
The present study has been designed and carried out to investigate the protective role of taurine (2-aminoethanesulphonic acid) against NaAsO2 induced nephrotoxicity. Oral administration of arsenic increased the productions of ROS and RNS, enhanced lipid peroxidation, protein carbonylation and decreased intracellular antioxidant defence in the kidney tissue. Investigating the responsible signalling cascades, it was found that NaAsO2 administration activates mitogen-activated protein kinases (MAPKs) and NF-κB in oxidative stress mediated renal dysfunction and induced apoptotic cell death by the reciprocal regulation of Bcl-2/Bad in association with reducing mitochondrial membrane potential and increased cytosolic cytochrome C as well. Treatment with taurine prior to arsenic administration effectively ameliorated As-induced oxidative renal dysfunctions and apoptotic cell death. Histological studies also support the experimental findings. Combining, results suggest that taurine possesses the ability to ameliorate arsenic-induced oxidative insult and renal damage, probably due to its antioxidant activity and functioning via MAPKs/NF-κB and mitochondria dependent pathways.
| Abbreviations | ||
| CAT | = | catalase |
| ERK | = | extracellular signal regulated protein kinases |
| FBS | = | Foetal bovine serum |
| FRAP | = | Ferric Reducing/Antioxidant Power |
| GSH | = | glutathione |
| GSSG | = | glutathione disulphide |
| GST | = | glutathione S-transferase |
| GPx | = | glutathione peroxidase |
| GR | = | glutathione reductase |
| HSD | = | hydroxysteroid dehydrogenase |
| MDA | = | malonaldehyde |
| MAPKs | = | mitogen-activated protein kinases |
| NF-κB | = | nuclear factor kappa B |
| ROS | = | reactive oxygen species |
| NaAsO2 | = | sodium arsenite |
| SOD | = | superoxide dismutase |
| TNF-α | = | tumour necrosis factor α |
| Abbreviations | ||
| CAT | = | catalase |
| ERK | = | extracellular signal regulated protein kinases |
| FBS | = | Foetal bovine serum |
| FRAP | = | Ferric Reducing/Antioxidant Power |
| GSH | = | glutathione |
| GSSG | = | glutathione disulphide |
| GST | = | glutathione S-transferase |
| GPx | = | glutathione peroxidase |
| GR | = | glutathione reductase |
| HSD | = | hydroxysteroid dehydrogenase |
| MDA | = | malonaldehyde |
| MAPKs | = | mitogen-activated protein kinases |
| NF-κB | = | nuclear factor kappa B |
| ROS | = | reactive oxygen species |
| NaAsO2 | = | sodium arsenite |
| SOD | = | superoxide dismutase |
| TNF-α | = | tumour necrosis factor α |