Plasma activated Ringer’s lactate solution

Abstract

Low-temperature plasma (LTP) has been widely used in life science. Plasma-activated solutions were defined as solutions irradiated with LTP, and water, medium, and Ringer’s solutions have been irradiated with LTP to produce plasma-activated solutions. They contain chemical compounds produced by reactions among LTP, air, and solutions. Reactive oxygen and nitrogen species (RONS) are major components in plasma-activated solutions and recent studies revealed that plasma-activated organic compounds are produced in plasma-activated Ringer’s lactate solution (PAL). Many in vitro and in vivo studies demonstrated that PAL exhibits anti-tumor effects on cancers, and biochemical analyses revealed intracellular molecular mechanisms of cancer cell death by PAL.

Keywords:

• plasma-activated Ringer’s lactate solution
  

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was partly supported by a Grant-in-Aid for Specially Promoted Research [No. 19H05462] and a Grant-in-Aid for Scientific Research (B) [No. 21H01072] from the Ministry of Education, Culture, Sports, Science and Technology of Japan, as well as the Joint Usage/Research Program of the Center for Low-temperature Plasma Science, Nagoya University, and the Plasma-Bio Consortium.