A new polymorph of isoimperatorin

Abstract

Isoimperatorin is a naturally occurring furocoumarin and is being considered as a potential chemoprevention. Only one crystal form of isoimperatorin (Form I) was reported during previous research so that an investigation of polymorphism of isoimperatorin was successfully undertaken. A new polymorph of isoimperatorin was discovered through comprehensive polymorph screening experiments. Their structures were elucidated by single-crystal structure analysis and extensively characterized by XRPD, DSC, FT-IR, and SEM. The results showed that the crystal structure and thermal properties of the new polymorph (Form II) were significantly different from those of Form I. Thermodynamic stability and phase transformation were also discussed in detail.

Keywords:

• Isoimperatorin
• polymorph
• X-ray diffractometry
• differential scanning calorimetry
• FT-IR

Acknowledgements

The authors are very thankful to Analysis Center in Beijing University of Chemical Technology.

Disclosure statement

The authors have declared that there is no conflict of interest.

Additional information

Funding

This work was financially supported by the Collaborative Innovation Construction Plan of Beijing University of Chinese Medicine [grant No. 2013-XTCX-03].