Ammonio Polymethacrylate-Coated Diltiazem: Drug Release from Single Pellets, Media Dependence, and Swelling Behavior

Abstract

Drug release from single pellets was measured on an easily assembled flow-through system. Despite heterogeneity between pellets, the sum of the individual results resembled drug release from an ensemble. A typical pellet displayed a long lag followed by rapid release. Heterogeneity appeared to result from substrate properties rather than coating uniformity. Swelling behavior in acid and buffer was measured by dynamic image analysis and related to drug release. Drug release was sensitive to dissolution temperature but swelling was not. A description of the drug release process was proposed.

Keywords:

• Single-pellet dissolution
• multiparticulate
• swelling
• drug release