Physicochemical investigation of the solid dispersion systems of etoricoxib with poloxamer 188

Abstract

Solid dispersion systems of a poorly water-soluble drug, etoricoxib were prepared with poloxamer 188 in 1:0.5, 1:1.5 and 1:2.5 ratios and evaluated by FTIR, powder XRD and dissolution studies. Physical studies demonstrated a strong hydrogen bonding with significant decrease in the crystallinity and formation of amorphous etoricoxib in its binary systems. All binary systems of etoricoxib showed faster dissolution than pure drug alone (P < 0.001). However, 1:2.5 proportion of etoricoxib: poloxamer 188 showed superior performance (DE₄₅: 71.27% ± 3.85) in enhancing solubility and dissolution rate of etoricoxib suggesting optimum ratio of the carrier.

Keywords::

• Etoricoxib
• solid dispersion
• poloxamer
• dissolution
• amorphous

Acknowledgements

The authors are thankful to Shivaji University, Kolhapur, Maharashtra, India, for providing FTIR and XRD facilities. Authors are very much thankful to Principal, Govt. College of Pharmacy, Karad, Maharashtra, India, for providing laboratory facilities and constant encouragement.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.