Drug metabolism and pharmacokinetics

Abstract

In this article, aspects of absorption, distribution, metabolism, and excretion have been described bearing in mind the pathogenesis of allergic diseases and their possible therapeutic opportunities. The importance of the routes of administration of the different therapeutic groups has been emphasized. The classical aspects of drug metabolism and disposition related to oral administration have been reviewed, but special emphasis has been given to intranasal, cutaneous, transdermal, and ocular administration as well as to the absorption and the subsequent bioavailability of drugs. Drug-metabolizing enzymes and transporters present in extrahepatic tissues, such as nasal mucosa and the respiratory tract, have been particularly discussed. As marketed antiallergic drugs include both racemates and enantiomers, aspects of stereoselective absorption, distribution, metabolism, and excretion have been discussed. Finally, a new and promising methodology, microdosing, has been presented, although it has not yet been applied to drugs used in the treatment of allergic diseases.

Keywords::

• Compartmental and noncompartmental pharmacokinetics
• sites of administration
• absorption
• distribution
• metabolism
• excretion
• transporters
• chronopharmacokinetics
• enantiomers
• microdosing

Acknowledgements

Declaration of interest: The authors report no financial conflicts of interest. The authors alone are responsible for the content and writing of this paper.