Abstract
This paper describes our experience with an evidence-based Adult Alcohol Withdrawal Syndrome Practice Guideline in an academic medical center. Combined data from two pilot studies demonstrate the efficacy of this approach for hospitalized patients. One hundred-six guideline-managed patients (pilot) were compared with 82 non-guideline managed patients (control). Pilot patients received significantly less benzodiazepine and significantly more clonidine. Significantly more pilot (34%) than control patients (11%) required no drug therapy to manage or prevent AWS symptoms. Adverse events were similar between groups. Control patients required significantly more sitters. These data suggest that hospitalized patients at risk for AWS can be effectively managed with a standardized, symptom-triggered approach.