Increases in serum concentration of human heart-type fatty acid-binding protein following elective coronary intervention

Abstract

Background: Heart-type fatty acid-binding protein (H-FABP) is considered a marker of myocardial necrosis but whether or not it is modified by myocardial ischemia is not clear. We sought to investigate if H-FABP serum levels increase following non-urgent coronary angioplasty.

Methods: We studied 31 patients undergoing coronary angioplasty. Peripheral venous samples were drawn immediately before angioplasty, 1 h after the first balloon inflation and 24 h after the procedure and assayed for H-FABP.

Results: Serum levels of H-FABP increased significantly at 1 h vs baseline from 2554 ± 1268 to 3322 ± 245 pg ml⁻¹ (p = 0.024). However, no differences were observed between 1 h and 24 h after angioplasty (3268 ± 1861 vs 3322 ± 2459 pg ml⁻¹, p = 0.87). Moreover, no significant difference was observed when we compared 24 h after angioplasty with the baseline (3268 ± 1861vs 2554 ± 1268 pg ml⁻¹, p = 0.112).

Conclusions: We conclude that H-FABP significantly increases after elective coronary angioplasty at 1 h compared with baseline values; whether or not this has any prognostic significance for future events, as it occurs with troponins, needs to be studied further.

Keywords::

• Biomarkers
• heart-type fatty acids
• angioplasty

Acknowledgments

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.