Caveolin-1 polymorphisms in patients with severe obstructive sleep apnea

Abstract

Objective: To investigate the associations of G14713A and T29107A polymorphic variants of Caveolin-1 with severe obstructive sleep apnea (OSA).

Materials and methods: This study was performed on 86 severe OSA patients and 86 controls. Genotyping was performed to investigate the association of G14713A and T29107A polymorphisms of Caveolin-1 with severe OSA.

Results: The distribution of genotypes of T29107A was significantly different between controls and OSA patients with a higher proportion of TT carriers in the OSA group.

Conclusion: T29107A-specific genotype of Caveolin-1 may be linked with severe OSA pathogenesis.

Keywords:

• G14713A
• genotype
• polymorphic variant
• T29107A

Acknowledgements

The English in this document has been checked by at least two professional editors, both native speakers of English.

Disclosure statement

The authors report no declarations of interest.