Low-dose oral contraceptive-induced acute myocardial infarction

Abstract

Objectives: Since their introduction, oral contraceptives (OCs) have been associated with risk to both the venous and the arterial systems. Studies have shown that OC use is associated with a risk of venous thromboembolism, ischaemic stroke and acute myocardial infarction (MI). MI is rarely seen in patients using OCs, particularly in the absence of clinical risk factors or smoking.

Case: We report a case of acute inferior MI in a 20-year-old non-smoker who had used a low-dose OC (3 mg drospirenone and 30 μg ethinyl estradiol) for 1 month. As far as we know, this is the youngest case of acute MI associated with a low-dose OC.

Conclusion: Low-dose OCs may also be responsible for acute MI even in a very young female without any cardiovascular risk factors. Therefore, the clinicians should be aware of this mortal events during follow-up of the patient using OCs.

Chinese abstract

目的: 自口服避孕药 (OCs) 引入以来就与静脉和动脉系统的风险有关。研究已经表明OC应用与静脉血栓栓塞, 缺血性中风及急性心肌梗塞 (MI) 的风险有关。正在应用OCs的患者尤其是缺少临床危险因素或者吸烟的患者很少发现MI。

案例: 我们报道了一个20岁已经应用低剂量 (3mg屈螺酮和30μg炔雌醇) OC一个月的不吸烟的急性前壁MI案例。据我们所知这是急性MI与低剂量OC相关的最年轻的案例。

结论: 低剂量OCs即使是在没有任何心血管危险因素的非常年轻的女性也可以是急性MI的原因。因此, 临床医生在对使用OCs病人的随访中应该对这种致命事件的发生有意识。

Keywords:

• Acute myocardial infarction
• low-dose oral contraceptives
• thromboembolism
• youngest case

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.