Gender differences in empathy and clinical symptoms in chronic schizophrenia patients: a large sample study based on a Chinese Han population

Abstract

Background

Empathy is social cognition and reduced empathy in schizophrenia (SCZ) has been noted; however, whether there are gender differences in empathy remains unclear. Therefore, the purpose of this study was to explore this issue by examining a large sample of the population with SCZ.

Methods

We recruited 987 SCZ patients (M/F = 638/349). The empathy was assessed by The Interpersonal Reactivity Index (IRI). The Positive and Negative Syndrome Scale (PANSS) was adopted to assess their clinical psychiatric symptoms and their ability to recognise the facial emotions of others was assessed by the Pictures Of Facial Affect (POFA).

Results

Female SCZ patients had higher IRI total score than male patients. In male patients, Pearson correlation analysis showed that empathy was negatively correlated with PANSS total score and negative symptom subscale scores, but positively correlated with anger identification. In female patients, IRI total score was negatively correlated with PANSS total score as well as its positive and negative symptom subscale scores (all p < 0.05).

Conclusion

There are gender differences in the empathy of SCZ patients, with female patients having greater empathy and a correlation with their clinical symptoms. This gender difference may provide potential clinical value for the treatment of SCZ.

KEY POINTS

• Female SCZ were more likely to empathise than males;

• Female patients had more severe clinical symptoms than males;

• There were gender differences in the association between certain specific clinical presentations and empathy.

• In future studies, it may be useful to investigate gender differences in schizophrenia empathy for the diagnosis and treatment of the disorder.

Keywords:

• Schizophrenia
• empathy
• gender difference
• clinical symptoms

Acknowledgements

The authors would like to thank Yongjie Zhou, Pallavi B. Ganapathi, Hanjing Emily Wu, Huanzhong Liu and Dongmei Wang for all of their hard work and significant contributions toward the study.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Concise description

Empathy, an important component of social cognition, is generally reduced in patients with schizophrenia, and is strongly associated with patients’ clinical symptoms. There are relatively few studies on the relationship between empathy and clinical symptoms in Chinese patients with schizophrenia. Moreover, there are no studies on gender differences in the association between empathy and clinical symptoms in Chinese schizophrenia patients.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

Funding for this study was provided by the National Key Research and Development Program of China [2017YFC1310405].