Comparison between Aspergillus fumigatus conidia and hyphae susceptibilities to amphotericin B, itraconazole, and voriconazole by use of the mold rapid susceptibility assay

Tracy J. Wetter, Kevin C. Hazen and Jim E. Cutler

Medical Mycology, 2005, 43(6), 525–532

The publishers would like to apologise for the omission of two tables from the above-mentioned article. The tables are shown in full below.

Table 1 hRSA MIC value ranges of Aspergillus fumigatus hyphae at 48 h^a

Strain Number	0.11 OD530nm C.I. dilution^b	AMB MIC Range	ITC MIC Range	VRC MIC Range
NCPF 7098	1:1	>16 µg/ml	>16 µg/ml	>16 µg/ml
	1:10	2	0.25–0.5	0.25– > 16
	1:50	0.5–1	0.125–0.25	0.25–0.5
	1:100	0.5–1	0.125–0.25	0.25
	1:200	0.25	0.125–0.25	0.25
	1:1000	0.125–0.25	0.125–0.25	0.25
NCPF 7100	1:1	4– > 16	>16	>16
	1:10	1–2	>16	2
	1:50	0.5	>16	1
	1:100	0.5–1	>16	1
	1:200	0.25	>16	1
	1:1000	0.25	>16	1
NCPF 7101	1:1	>16	2– > 16	8– > 16
	1:10	4	0.5	0.5–1
	1:50	0.5–1	0.25	0.25–0.5
	1:100	0.5–1	0.125–0.25	0.25–0.5
	1:200	0.5	0.125–0.25	0.25–0.5
	1:1000	0.25–0.5	0.125–0.25	0.25
NCPF 7097	1:1	>16	>16	2– > 16
	1:10	4–8	0.5–1.0	0.5
	1:50	2	0.25–0.5	0.5
	1:100	1	0.125	0.5
	1:200	0.5–1	0.125	0.25–0.5
	1:1000	0.5–1	0.125	0.25

^aTesting performed three times, in duplicate.

^bC.I. Dilution, Conidial inoculum dilution.

Table 2 Comparison of conidial and hyphal MIC values^a

Strain	Antifungal		hRSA MIC
Number	Drug	cRSA MIC	1:50^b	1:200
NCPF 7098	AMB	0.5 µg/ml	1.0 µg/ml	0.25 µg/ml
	ITC	0.5	0.25	0.25
	VRC	0.25	0.5	0.25
NCPF 7100	AMB	0.5	0.5	0.25
	ITC	>16.0	>16.0	>16.0
	VRC	0.5	1.0	1.0
NCPF 7101	AMB	0.5	1.0	0.5
	ITC	0.5	0.25	0.25
	VRC	0.25	0.5	0.5
NCPF 7097	AMB	0.5	2.0^c	1.0
	ITC	0.5	0.5	0.25
	VRC	0.25	0.5	0.5

^aGeometric mean. Testing performed three times, in duplicate.

^b0.11 OD_530nm conidial inoculum dilution used in hyphal inoculum preparation.

^chRSA MIC significantly higher than cRSA MIC.