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Medical Mycology Volume 46, 2008 - Issue 2
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Amphotericin B-deoxycholate overdose due to administration error in pediatric patients

Susanne Groeneveld Departments of Pediatrics, the Nijmegen University Center of Infectious Disease, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands
,
Paul E. Verweij Medical Microbiology, the Nijmegen University Center of Infectious Disease, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands; the Nijmegen University Center of Infectious Disease, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands
,
Louis Van't Hek Pediatric Intensive Care, the Nijmegen University Center of Infectious Disease, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands
,
Jos P.M. Bökkerink Pediatric Oncology, the Nijmegen University Center of Infectious Disease, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands
&
Adilia Warris Departments of Pediatrics, the Nijmegen University Center of Infectious Disease, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands; the Nijmegen University Center of Infectious Disease, Radboud University Nijmegen Medical Center, Nijmegen, the NetherlandsCorrespondence[email protected]
, PhD , MD
Pages 185-187 | Received 18 May 2007, Published online: 09 Jul 2009
 

Abstract

Due to the similarity of their generic names, the use of amphotericin B-deoxycholate and liposomal amphotericin B could cause confusion in daily practice. We report two cases of amphotericin B-deoxycholate overdose in infants due to administration errors which raises the issue that the use of this antifungal agent should be questioned because of its severe side effects.

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