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Medical Mycology Volume 46, 2008 - Issue 6
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Case Reports

A case of pulmonary cryptococcosis followed by pleuritis in an apparently immunocompetent patient during fluconazole treatment

Koichi Izumikawa Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, JapanCorrespondence[email protected]
,
Yong Zhao Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
,
Kohei Motoshima Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
,
Takahiro Takazono Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
,
Tomomi Saijo Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
,
Sintaro Kurihara Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
,
Shigeki Nakamura Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
,
Taiga Miyazaki Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
,
Masafumi Seki Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
,
Hiroshi Kakeya Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
,
Yoshihiro Yamamoto Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
,
Katsunori Yanagihara Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan; Department of Laboratory Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
,
Yoshitsugu Miyazaki Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
,
Tomayoshi Hayashi Department of Pathology, Nagasaki University School of Medicine, Nagasaki, Japan
&
& Shigeru Kohno Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
 show all
Pages 595-599 | Received 11 Oct 2007, Published online: 09 Jul 2009
 

Abstract

Cryptococcal pleuritis is rare in individuals with no underlying disease. We report a case of pulmonary cryptococcosis followed by pleuritis in a patient on fluconazole treatment. Biopsy of the pleura revealed a granuloma and a cryptococcal body, while PCR and sequence analysis of extracted DNA from the pleura proved the presence of Cryptococcus species, most likely C. neoformans. Voriconazole with flucytosine and drainage of the pleural effusion were effective in treating the patient.

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