Effect of surgical menopause and frontal lobe cognitive function

Abstract

Objective

This study aims to explore the prevalence of decreased frontal lobe function and its associated factors in women with surgical menopause.

Methods

This study is a retrospective analysis of a cross-sectional study conducted between October 2013 and July 2014. Data from 164 women with surgical menopause were analyzed. The Montreal Cognitive Assessment Thai version (MoCA-T) test was administered by a psychologist. The MoCA frontal lobe function score was derived from visuospatial/executive, abstraction, attention, and verbal fluency tests. Multivariable logistic regression was used to assess data associated with decreased frontal lobe function.

Results

The mean age of participants was 56.3 ± 6.9 years, and the mean time since menopause was 11.3 ± 7.4 years. The prevalence of decreased frontal lobe function score was 73.8%, with an average score of 6.21 ± 1.84. The independent factor associated with a lower MoCA frontal lobe function score was duration of education greater than 6 years.

Conclusion

Our study adds information about decreased frontal lobe function in almost three-quarters of women with surgical menopause. Duration of education greater than 6 years was a protective factor. Menopause hormone therapy usage did not seem to increase the detrimental effect on frontal lobe function when initiated in young women with surgical menopause.

摘要

目的：本研究旨在探讨手术绝经女性额叶功能减退的发生率及其相关因素。

方法：本项研究是对2013年10月至2014年7月间的横断面研究进行回顾性分析。对164名手术绝经女性的数据进行了分析。由心理学家进行蒙特利尔认知评估泰语版（MoCA-T）测试, MoCA的额叶功能评分来自视觉空间/执行、抽象、注意和语言流利性测试。多变量logistic回归用于评估与额叶功能下降相关的数据。

结果：研究对象的平均年龄为56.3±6.9岁, 平均绝经时间11.3年± 7.4年。额叶功能评分下降的发生率为73.8%, 平均6.21分± 1.84。与MoCA额叶功能评分较低相关的独立因素是教育年限大于6年。

结论：我们的研究补充信息发现近四分之三手术绝经女性发生额叶功能下降。教育年限超过6年是一个保护因素。对于手术绝经年轻女性应用绝经激素治疗的似乎不增加对额叶的不利影响。

Keywords:

• Surgical menopause
• cognition
• frontal lobe
• Montreal Cognitive Assessment

Potential conflict of interest

The authors report no conflict of interest.

Additional information

Funding

Nil.