The ocular involvement did not accompany with the genital ulcer or the gastrointestinal symptoms at the early stage of Behçet’s disease

Abstract

Objectives: This study aimed to identify patients with high-probability of ocular involvement of Behçet’s disease (BD).

Methods: The Japanese Ministry of Health, Labour and Welfare provided dataset of ongoing nationwide BD registration project. A patient who had confirmed BD and who was suspected to have BD was registered. We mainly analyzed newly registered patients who had the data for all demographic and diagnostic parameters regardless of fulfilment of any diagnostic criteria.

Results: Among 3213 patients with confirmed or possible BD, 1382 (43.0%) were men and 1831 (57.0%) were women with a median age of 38 years (interquartile range (IQR) 30–49 years). The median duration between onset and registration was 0 year (IQR 0–3). A binomial multivariable logistic regression analysis revealed that being female (odds ratio (OR) 0.63, 95% confidence interval (CI) 0.53–0.75, p < .001), duration since onset (OR 1.33 per 10 years, 95% CI 1.18–1.51, p < .001), genital ulceration (OR 0.28, 95% CI 0.23–0.34, p < .001), and gastrointestinal symptoms (OR 0.36, 95% CI 0.30–0.44, p < .001) were related to the ocular lesion. Analyses based on data of 2800 patients who satisfied International criteria of BD, age-, sex-, duration-based subgroup analyses, analyses targeting iridocyclitis and retino-uveitis, and analysis including patients with missing data confirmed that the four factors were associated with the probability of eye involvement.

Conclusion: The ocular involvement did not accompany with genital ulcer or gastrointestinal symptoms at the early stage of BD.

Keywords:

• Behçet’s syndrome
• uveitis
• epidemiology
• surveys and questionnaires

Acknowledgements

This work was partly supported by the Health and Labour Sciences Research Grants (Research on Intractable Diseases) from the MHLW of Japan.

Conflict of interest

None.

Additional information

Funding

This work was supported by JSPS KAKENHI Grant. We would also like to thank Japan Foundation for Applied Enzymology for the support in the form of grant.