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Modern Rheumatology Volume 30, 2020 - Issue 2
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Original Articles: Rheumatoid Arthritis

The correlation between interleukin-34 and bone erosion under ultrasound in rheumatoid arthritis

Na LiDepartment of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China; ;Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China; ;The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China
,
Li JiangDepartment of Rheumatology, Linyi People's Hospital, Shandong, China; ;Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China;
,
Yehua CaiInstitute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China; ;Department of Ultrasound, Huashan Hospital, Fudan University, Shanghai, China;
,
Jia Yan LiuDepartment of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China; ;Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China;
,
Tianyi ZhaoDepartment of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China; ;Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China;
,
Ning KongDepartment of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China; ;Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China;
,
Yiyun YuDepartment of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China; ;Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China;
,
Dan Dan XuanDepartment of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China; ;Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China;
,
Hejian ZouDepartment of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China; ;Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China;
,
Yu XueDepartment of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China; ;Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China; Correspondence[email protected]
&
Weiguo WanDepartment of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China; ;Institute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China; Correspondence[email protected]
 show all
Pages 269-275 | Received 14 Sep 2018, Accepted 08 Mar 2019, Published online: 16 Apr 2019
 
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Abstract

Background: Rheumatoid arthritis (RA) is a chronic inflammatory arthropathy characterized by excessive synovial hyperplasia and progressive joint destruction. Pro-inflammatory cytokines play major roles in the regulation of synovial inflammation. The contribution of interleukin-34 (IL-34) in RA pathogenesis has been strongly suggested in clinical studies.

Aim: To investigate the correlation between plasma IL-34 and disease parameters in RA patients including disease activity score (DAS28), receptor activator of NF-κB ligand (RANKL) concentration, synovitis and bone erosions under ultrasound.

Methods: 60 RA patients and 20 healthy controls were from Huashan Hospital, patient's medical history, physical examination, laboratory examination and ultrasound data were collected and recorded, respectively. Blood samples of all participants were collected and the levels of IL-34 and RANKL were tested. The levels of IL-34 and RANKL in RA patients were compared with those of healthy controls. Furthermore, the correlation between IL-34, RANKL and disease parameters in RA patients was analyzed.

Results: Both plasma levels of IL-34 and RANKL in RA patients were significantly higher than the healthy controls (p < .05). IL-34 was significantly related to disease activity scores (r = 0.43, p = .001); RANKL (r = 0.46, p = .0003) and bone erosions by ultrasound (r = 0.38, p = .002).

Conclusions: The plasma IL-34 concentration in RA was significantly higher than the healthy controls and was significantly correlated with RANKL, as well as disease activity score and bone erosions by ultrasound. The IL-34 may be a new biological marker for disease activity and predictor for bone erosions in RA. Targeting IL-34 holds promise in the management of RA and, potentially, other osteoclasts driven diseases (erosive osteoarthritis and psoriatic arthritis for example).

Conflict of interest

None.

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