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Abstract
Depressive disorders are more common in women than men. The reasons for this gender difference are explored from a biological, psychological, sociocultural and occupational science perspective. The unique features of depression for women include not only differences in symptom profile, but also in the course and response to treatment. Moreover, the resultant severity of symptoms impedes recovery and causes more functional impairment for women. The concept of work‐life balance including practical aspects of time crunches as well as perceptual aspect of feeling overwhelmed is explored in an effort to understand this phenomenon. The costs associated with work‐life conflict as well as the gender differences with women having more work‐life conflict then men are reviewed. The application of the occupational science perspective in the understanding of the unique features of impairment and dysfunction for women with depression is reviewed through case example.