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Cytotherapy Volume 8, 2006 - Issue 3
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Letter to the Editor

Autologous transplantation of CD133+ BM-derived stem cells as a therapeutic option for dilatative cardiomyopathy

A Ghodsizad Department of Cardiovascular and Thoracic Surgery
,
A Ruhparwar Department of Cardiovascular and Thoracic Surgery, Medical School of Hanover, Hanover, Germany
,
R Marktanner Department of Cardiovascular and Thoracic Surgery
,
A Borowski Department of Cardiovascular and Thoracic Surgery
,
Mr Mohammad Hasani Department of Cardiovascular and Thoracic Surgery
,
L Poll Department of Diagnostic Radiology
,
I Vshivkov Department of Cardiovascular and Thoracic Surgery
,
V Stoldt Department of Transfusion Medicine, Heinrich-Heine-University of Duesseldorf, Duesseldorf, Germany
,
T Voelkel Department of Cardiovascular and Thoracic Surgery
,
C Piechaczek Department of Cardiovascular and Thoracic Surgery
,
Er Burchardt Department of Cardiovascular and Thoracic Surgery
,
M Stockschlaeder Department of Transfusion Medicine, Heinrich-Heine-University of Duesseldorf, Duesseldorf, Germany
,
C Sucker Department of Transfusion Medicine, Heinrich-Heine-University of Duesseldorf, Duesseldorf, Germany
,
E Gams Department of Cardiovascular and Thoracic Surgery
&
Hm Klein Department of Cardiovascular and Thoracic Surgery
 show all
Pages 308-310 | Published online: 07 Jul 2009
 

Abstract

We report the case of a 58-year-old man with end-stage non-ischemic cardiomyopathy. Baseline transthoracic echocardiography (TTE) and cardiac magnetic resonance (cMRI) revealed a markedly depressed left ventricle systolic function. He underwent autologous CD133+ BM-derived cell transplantation through a minimally invasive approach. During surgery 19×106 BM-derived stem cells were injected by the transepimyocardial route. Six months after the operation TTE and cMRI showed a clear improvement in left ventricular contractility.

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