Autologous activated platelet-rich plasma (AA-PRP) and non-activated (A-PRP) in hair growth: a retrospective, blinded, randomized evaluation in androgenetic alopecia

ABSTRACT

Objectives: A retrospective case-series study comparing autologous activated platelet-rich plasma (AA-PRP) versus autologous non-activated platelet-rich plasma (A-PRP) in hair re-growth was reported.

Methods: 90 patients, 63 males showing AGA in stage I–V by the Norwood–Hamilton scale and 27 females with AGA in stage I–III by the Ludwig scale, treated since 2013, were analyzed. 57 patients were treated with A-PRP injections and 33 patients were treated with AA-PRP in three sessions spaced 30 days average. Assessment of hair re-growth was evaluated in different weeks (Ws) after the treatment, summarized in four phases: T0, before the first infusion, T1 – 12 Ws, T2 – 23 Ws, T3 – 44 Ws, T4 – 58 Ws after the last treatment.

Results: 12 Ws, 23 Ws, 44 Ws, and 58Ws after the last treatment, hair density measurements for patients treated with A-PRP and AA-PRP were 65 ± 5 and 28 ± 4 hairs/cm2 at T1, 28 ± 2 and 15 ± 3 hairs/cm2 at T2, 25 ± 3 and 14 ± 3 hairs/cm2 at T3, 23 ± 3 and 13 ± 3 hairs/cm² at T4.

Conclusion: The effects of A-PRP and AA-PRP in hair re-growth during a long-term follow-up, was demonstrated.

KEYWORDS:

• Hair
• Platelet rich plasma
• hair loss
• hair regrowth
• PRP hair loss
• PRP hair re-growth

Authors’ contributions

PG designed the studies, performed the procedures, analyzed the results, wrote the paper, wrote editing review, performed the tricoscan data analysis and conducted the study as leader. SG analyzed the results, performed the tricoscan evaluation. All authors have approved the final draft submitted.

Acknowledgments

The authors would like to acknowledge all parties that participated in this study.

This work has been wrote totally by researcher Pietro Gentile, independent mind, exclusively on the basis of scientific and clinical results obtained.

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Reviewer Disclosures

Peer reviewers on this manuscript have no relevant financial relationships or otherwise to disclose.

Additional information

Funding

This paper was not funded.