Impact of tumor size on the outcome of patients with small renal cell carcinoma

ABSTRACT

Background: ​This study aims to establish potential correlation between tumor size and outcomes in patients with T1a kidney cancer registered within the surveillance, epidemiology and end results (SEER) database.

Methods: SEER database (2004-2013) has been accessed through SEER*Stat program to determine the correlation between tumor size and cancer-specific survival in patients with T1a kidney cancer.  Survival analysis was conducted through Kaplan-Meier analysis and log-rank testing.

Results: Five year kidney cancer-specific survival rates show progressive decline with increasing tumor size.  Moreover, kidney cancer-specific survival has been compared according to the initial local treatment modality (observation, ablation, partial or radical nephrectomy) across different size categories (<1 cm, 1-2 cm, 2-3 cm and 3-4 cm).  Survival curves of different treatment modalities were almost overlapping for patients with renal mass < 1cm. For patients with tumor size 1-2 cm, treatment modalities were overlapping at the first 60 months then the curve of observation diverged (P <0.0001). For patients with tumor size 2-3 cm and 3-4 cm, the curve of observation diverged early in the time course (P <0.0001).

Conclusion: Primary tumor size is an important factor that should be taken into consideration when evaluating the different treatment options for patients with small kidney cancers.​

KEYWORDS:

• Renal cancer
• observation
• ablation
• surgery

Declaration of interest

The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Additional information

Funding

This article has not received any funding.