Cardiovascular mortality trends in non-Hodgkin’s lymphoma: a population-based cohort study

ABSTRACT

Background: Non-Hodgkin’s lymphoma (NHL) survivors are at a higher risk of cardiovascular diseases (CVDs).

Methods: A population-based study was conducted to investigate the cardiovascular mortality trends to identify NHL survivors at the highest risk.

Results: The CVDs mortality was the second most common cause of death (13.07%) after NHL. There were more patients ≥ 60 years old in the cardiovascular group (87.2%), P < 0.001. Patients who died from CVDs had the best survival while patients who died from NHL had a significantly lower mean survival. The overall survival rate was 92.4%. Consistently, older age, unmarried, male patients, not recently diagnosed with NHL and not receiving radiation and/or surgery were associated with a worse survival across all models. The black race and stage IV only had a worse cardiovascular specific survival (CVSS).

Conclusions: Although the CVSS improved over time, the mortality from the CVDs is still the second most common cause of death after NHL. Older age, not married, black, male patients, not recently diagnosed with NHL, with an advanced stage and not receiving radiation and/or surgery were associated with a worse survival. Risk factor modification along with CVDs screening should be intensified in NHL patients with these mortality predictors.

KEYWORDS:

• Non-Hodgkin’s lymphoma
• cardiovascular
• mortality
• SEER
• survival

Acknowledgments

We are grateful to the native English speakers of Online Research Club (onlineresearchclub.org) to carefully review our paper and correcting it.

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.

Author contributions

MGK was the responsible for the idea and study design. All authors determined the inclusion and exclusion criteria under the supervision of NTH. MGK got the data from SEER and prepared it for the analysis. MGK analyzed the data and interpreted it with NTH. All authors shared in the manuscript writing and approved the final version.

Supplemental data

Supplemental data for this article can be accessed here.

Additional information

Funding

This manuscript has not received funding.